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Is 2,3,7,8-TCDD (dioxin) a carcinogen for humans?

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has suddenly become the focal point of controversy over the relationship of chemical waste to human health. Specific concern exists regarding its potential association with human malignancy. Subcellular, cellular, and whole-animal experiments suggest that T...

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Detalles Bibliográficos
Autores principales: Ayres, S M, Webb, K B, Evans, R G, Mikes, J
Formato: Texto
Lenguaje:English
Publicado: 1985
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568683/
https://www.ncbi.nlm.nih.gov/pubmed/3910419
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author Ayres, S M
Webb, K B
Evans, R G
Mikes, J
author_facet Ayres, S M
Webb, K B
Evans, R G
Mikes, J
author_sort Ayres, S M
collection PubMed
description 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has suddenly become the focal point of controversy over the relationship of chemical waste to human health. Specific concern exists regarding its potential association with human malignancy. Subcellular, cellular, and whole-animal experiments suggest that TCDD exerts much of its activity by inducing enzymes that protect the intact organism from the assault of environmental contamination. TCDD is a potent inducer of aryl hydrocarbon hydroxylase, although wide variations between species do exist. Conventional tests for mutagenicity have produced conflicting results. Animal experiments have shown the development of tumors following chronic low level ingestion of TCDD. The human evidence regarding the potential carcinogencity of TCDD comes from occupational, military and environmental exposures. Several studies have come out of Sweden suggesting an association between sarcoma and exposure to herbicides. Although there is little solid evidence that 2,3,7,8-TCDD produces substantial chronic disability or premature death in man, a significant body of experimental evidence for its carcinogenicity makes it likely that a small number of human malignancies may be due to its action. Since 2,3,7,8-TCDD is an unwanted contaminant it could be eliminated with little measurable consequence.
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spelling pubmed-15686832006-09-18 Is 2,3,7,8-TCDD (dioxin) a carcinogen for humans? Ayres, S M Webb, K B Evans, R G Mikes, J Environ Health Perspect Research Article 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has suddenly become the focal point of controversy over the relationship of chemical waste to human health. Specific concern exists regarding its potential association with human malignancy. Subcellular, cellular, and whole-animal experiments suggest that TCDD exerts much of its activity by inducing enzymes that protect the intact organism from the assault of environmental contamination. TCDD is a potent inducer of aryl hydrocarbon hydroxylase, although wide variations between species do exist. Conventional tests for mutagenicity have produced conflicting results. Animal experiments have shown the development of tumors following chronic low level ingestion of TCDD. The human evidence regarding the potential carcinogencity of TCDD comes from occupational, military and environmental exposures. Several studies have come out of Sweden suggesting an association between sarcoma and exposure to herbicides. Although there is little solid evidence that 2,3,7,8-TCDD produces substantial chronic disability or premature death in man, a significant body of experimental evidence for its carcinogenicity makes it likely that a small number of human malignancies may be due to its action. Since 2,3,7,8-TCDD is an unwanted contaminant it could be eliminated with little measurable consequence. 1985-10 /pmc/articles/PMC1568683/ /pubmed/3910419 Text en
spellingShingle Research Article
Ayres, S M
Webb, K B
Evans, R G
Mikes, J
Is 2,3,7,8-TCDD (dioxin) a carcinogen for humans?
title Is 2,3,7,8-TCDD (dioxin) a carcinogen for humans?
title_full Is 2,3,7,8-TCDD (dioxin) a carcinogen for humans?
title_fullStr Is 2,3,7,8-TCDD (dioxin) a carcinogen for humans?
title_full_unstemmed Is 2,3,7,8-TCDD (dioxin) a carcinogen for humans?
title_short Is 2,3,7,8-TCDD (dioxin) a carcinogen for humans?
title_sort is 2,3,7,8-tcdd (dioxin) a carcinogen for humans?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568683/
https://www.ncbi.nlm.nih.gov/pubmed/3910419
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