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Chromosomal aberrations and bone marrow toxicity.

The importance of chromosomal aberrations as a proximate cause of bone marrow toxicity is discussed. Since chemicals that can cause nondisjunction are rare, numerical aberrations (aneuploidy, polyploidy) are not ordinarily important. Many structural aberrations, however, can lead directly to cell de...

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Detalles Bibliográficos
Autores principales: Heddle, J A, Salamone, M F
Formato: Texto
Lenguaje:English
Publicado: 1981
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568739/
https://www.ncbi.nlm.nih.gov/pubmed/7238453
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author Heddle, J A
Salamone, M F
author_facet Heddle, J A
Salamone, M F
author_sort Heddle, J A
collection PubMed
description The importance of chromosomal aberrations as a proximate cause of bone marrow toxicity is discussed. Since chemicals that can cause nondisjunction are rare, numerical aberrations (aneuploidy, polyploidy) are not ordinarily important. Many structural aberrations, however, can lead directly to cell death and so are proximate causes of toxicity when they occur. The micronucleus test which utilizes the polychromatic erythrocyte is capable of detecting agents (clastogens) that can cause such structural aberrations. Many carcinogens can be detected by this test, and recent changes in the protocol may increase the success rate. Nevertheless only a small proportion of chemicals are clastogens. The importance of cell division in the expression of chromosomal damage and the stage of the cell cycle at the time of exposure on the amount of damage is emphasized. A speculative mechanism for the relationship between chromosomal aberrations and carcinogenicity is proposed.
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spelling pubmed-15687392006-09-19 Chromosomal aberrations and bone marrow toxicity. Heddle, J A Salamone, M F Environ Health Perspect Research Article The importance of chromosomal aberrations as a proximate cause of bone marrow toxicity is discussed. Since chemicals that can cause nondisjunction are rare, numerical aberrations (aneuploidy, polyploidy) are not ordinarily important. Many structural aberrations, however, can lead directly to cell death and so are proximate causes of toxicity when they occur. The micronucleus test which utilizes the polychromatic erythrocyte is capable of detecting agents (clastogens) that can cause such structural aberrations. Many carcinogens can be detected by this test, and recent changes in the protocol may increase the success rate. Nevertheless only a small proportion of chemicals are clastogens. The importance of cell division in the expression of chromosomal damage and the stage of the cell cycle at the time of exposure on the amount of damage is emphasized. A speculative mechanism for the relationship between chromosomal aberrations and carcinogenicity is proposed. 1981-06 /pmc/articles/PMC1568739/ /pubmed/7238453 Text en
spellingShingle Research Article
Heddle, J A
Salamone, M F
Chromosomal aberrations and bone marrow toxicity.
title Chromosomal aberrations and bone marrow toxicity.
title_full Chromosomal aberrations and bone marrow toxicity.
title_fullStr Chromosomal aberrations and bone marrow toxicity.
title_full_unstemmed Chromosomal aberrations and bone marrow toxicity.
title_short Chromosomal aberrations and bone marrow toxicity.
title_sort chromosomal aberrations and bone marrow toxicity.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568739/
https://www.ncbi.nlm.nih.gov/pubmed/7238453
work_keys_str_mv AT heddleja chromosomalaberrationsandbonemarrowtoxicity
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