Cargando…

Development of quantitative structure-pharmacokinetic relationships.

Quantitative structure-activity relationships (QSAR) relating biological activity to physiochemical descriptors have been successfully used for a number of years. It is also long recognized that pharmacokinetic parameters may play an important and even determinant role in drug action. This prompted...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mayer, J M, van de Waterbeemd, H
Formato:	Texto
Lenguaje:	English
Publicado:	1985
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568751/ https://www.ncbi.nlm.nih.gov/pubmed/3905378

Ejemplares similares

The diverse and expanding role of mass spectrometry in structural and molecular biology
por: Lössl, Philip, et al.
Publicado: (2016)

Partitioning and lipophilicity in quantitative structure-activity relationships.
por: Dearden, J C
Publicado: (1985)

Structure and assembly of scalable porous protein cages
por: Sasaki, Eita, et al.
Publicado: (2017)

Development and Validation of Quantitative Structure-Activity Relationship Models for Compounds Acting on Serotoninergic Receptors
por: Żydek, Grażyna, et al.
Publicado: (2012)

Interpretable correlation descriptors for quantitative structure-activity relationships
por: Spowage, Benson M, et al.
Publicado: (2009)

Quantitative Structure − Antiprotozoal Activity Relationships of Sesquiterpene Lactones (†)
por: Schmidt, Thomas J., et al.
Publicado: (2009)

Guidance for good practice in the application of machine learning in development of toxicological quantitative structure-activity relationships (QSARs)
por: Belfield, Samuel J., et al.
Publicado: (2023)

Advances in quantitative structure-property relationships
Publicado: (1996)

Cysteine Depletion Causes Oxidative Stress and Triggers Outer Membrane Vesicle Release by Neisseria meningitidis; Implications for Vaccine Development
por: van de Waterbeemd, Bas, et al.
Publicado: (2013)

Relationship Between Sunitinib Pharmacokinetics and Administration Time: Preclinical and Clinical Evidence
por: Kloth, Jacqueline S. L., et al.
Publicado: (2015)

Application of Machine Learning in Developing Quantitative Structure–Property Relationship for Electronic Properties of Polyaromatic Compounds
por: Nguyen, Tuan H., et al.
Publicado: (2022)

Everolimus pharmacokinetics and its exposure–toxicity relationship in patients with thyroid cancer
por: de Wit, D., et al.
Publicado: (2016)

Developing (Quantitative Structure Property Relationships) QSPR Techniques to Predict the Char Formation of Polybenzoxazines
por: Sairi, Maryam, et al.
Publicado: (2016)

A Review of Recent Advances towards the Development of (Quantitative) Structure-Activity Relationships for Metallic Nanomaterials
por: Chen, Guangchao, et al.
Publicado: (2017)

Development of Mass Spectrometry Selected Reaction Monitoring Method for Quantitation and Pharmacokinetic Study of Stepharine in Rabbit Plasma
por: Kopylov, Arthur T., et al.
Publicado: (2014)

The Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Relationships of Evacetrapib Administered as Monotherapy or in Combination With Statins
por: Friedrich, S, et al.
Publicado: (2014)

Quantitative Structure Activity Relationship Models for the Antioxidant Activity of Polysaccharides
por: Li, Zhiming, et al.
Publicado: (2016)

Quantitative structure–activity relationship-based computational approaches
por: Bastikar, Virupaksha, et al.
Publicado: (2022)

Impact of Linker Modification and PEGylation of Vancomycin Conjugates on Structure-Activity Relationships and Pharmacokinetics
por: Umstätter, Florian, et al.
Publicado: (2022)

Complementary Quantitative Structure–Activity Relationship Models for the Antitrypanosomal Activity of Sesquiterpene Lactones
por: Kimani, Njogu M., et al.
Publicado: (2018)

Quantitative PCR Analysis of DNA Aptamer Pharmacokinetics in Mice
por: Perschbacher, Katherine, et al.
Publicado: (2015)

“Quantitative Pharmacology: An introduction to integrative pharmacokinetic-pharmacodynamic analysis”
por: Lowe, P J
Publicado: (2012)

Some methods of obtaining quantitative structure-activity relationships for quantities of environmental interest.
por: Charton, M
Publicado: (1985)

Quantitative Structure–Activity Relationships for Structurally Diverse Chemotypes Having Anti-Trypanosoma cruzi Activity
por: de Souza, Anacleto S., et al.
Publicado: (2019)

Quantitative Residue-Level Structure–Evolution Relationships in the Yeast Membrane Proteome
por: Franzosa, Eric A., et al.
Publicado: (2013)

Multi-task learning with a natural metric for quantitative structure activity relationship learning
por: Sadawi, Noureddin, et al.
Publicado: (2019)

Development and Validation of a UPLC-MS/MS Method for the Quantitative Determination and Pharmacokinetic Analysis of Cirsimarin in Rat Plasma
por: Zhang, En, et al.
Publicado: (2021)

Pharmacokinetics and Concentration-Effect Relationship of Oral LSD in Humans
por: Dolder, Patrick C., et al.
Publicado: (2015)

Vancomycin pharmacokinetic model development in patients on intermittent online hemodiafiltration
por: Westra, Niels, et al.
Publicado: (2019)

Physiologically Based Pharmacokinetic Modeling Framework for Quantitative Prediction of an Herb–Drug Interaction
por: Brantley, S J, et al.
Publicado: (2014)

Sesquiterpene lactones of Aucklandia lappa: Pharmacology, pharmacokinetics, toxicity, and structure–activity relationship
por: Liu, Xin-nan, et al.
Publicado: (2021)

Quantitative Structure Retention-Relationship Modeling: Towards an Innovative General-Purpose Strategy
por: Kumari, Priyanka, et al.
Publicado: (2023)

Quantitative Structure–Activity Relationship Modeling of Kinase Selectivity Profiles
por: Kothiwale, Sandeepkumar, et al.
Publicado: (2017)

Quantitative Structure–Property Relationships for the Electronic Properties of Polycyclic Aromatic Hydrocarbons
por: Nguyen, Lam H., et al.
Publicado: (2018)

Genome-Wide Gene Expression Analysis of Bordetella pertussis Isolates Associated with a Resurgence in Pertussis: Elucidation of Factors Involved in the Increased Fitness of Epidemic Strains
por: King, Audrey J., et al.
Publicado: (2013)

Population Pharmacokinetics and Exposure-Response Relationships of Naldemedine
por: Kubota, Ryuji, et al.
Publicado: (2018)

Cytotoxic Activity and Quantitative Structure Activity Relationships of Arylpropyl Sulfonamides
por: Hwang, Yu Jin, et al.
Publicado: (2013)

Hemoglobin binding of arylamines and nitroarenes: molecular dosimetry and quantitative structure-activity relationships.
por: Sabbioni, G
Publicado: (1994)

Quantitative structure activity relationship and risk analysis of some pesticides in the goat milk
por: Muhammad, Faqir, et al.
Publicado: (2013)

Pharmacokinetic-dynamic relationship of cisplatin in vitro: simulation of an i.v. bolus and 3 h and 20 h infusion.
por: Ma, J., et al.
Publicado: (1994)

Cannot write session to /tmp/vufind_sessions/sess_hhf4nte8f2u0sufrtehqpcc7d1