2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) as a potent and persistent thyroxine agonist: a mechanistic model for toxicity based on molecular reactivity.

TCDD and thyroxine have common molecular reactivity properties which enable them to present a planar face and lateral halogens in interactions with proteins. These molecular properties are consistent with the structure-toxicity relationship for TCDD and related compounds. Biological evidence is disc...

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Detalles Bibliográficos
Autores principales: McKinney, J D, Fawkes, J, Jordan, S, Chae, K, Oatley, S, Coleman, R E, Briner, W
Formato: Texto
Lenguaje:English
Publicado: 1985
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568759/
https://www.ncbi.nlm.nih.gov/pubmed/2998749

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