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Modeling of dose-response relationships.
The main dose-response models for chronic toxicity are considered. For dichotomous response, the log probit, multi-hit, and multistage models are presented. For time-to-occurrence response, the log-normal and three variations of multistage models are presented. Finally, the Cornfield hockey-stick mo...
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Formato: | Texto |
Lenguaje: | English |
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1981
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568781/ https://www.ncbi.nlm.nih.gov/pubmed/7333256 |
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author | Altshuler, B |
author_facet | Altshuler, B |
author_sort | Altshuler, B |
collection | PubMed |
description | The main dose-response models for chronic toxicity are considered. For dichotomous response, the log probit, multi-hit, and multistage models are presented. For time-to-occurrence response, the log-normal and three variations of multistage models are presented. Finally, the Cornfield hockey-stick model is considered, and, for low-dose extrapolation, it is suggested that response be taken to be proportional to dose and to a power of time determined by background response. |
format | Text |
id | pubmed-1568781 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1981 |
record_format | MEDLINE/PubMed |
spelling | pubmed-15687812006-09-19 Modeling of dose-response relationships. Altshuler, B Environ Health Perspect Research Article The main dose-response models for chronic toxicity are considered. For dichotomous response, the log probit, multi-hit, and multistage models are presented. For time-to-occurrence response, the log-normal and three variations of multistage models are presented. Finally, the Cornfield hockey-stick model is considered, and, for low-dose extrapolation, it is suggested that response be taken to be proportional to dose and to a power of time determined by background response. 1981-12 /pmc/articles/PMC1568781/ /pubmed/7333256 Text en |
spellingShingle | Research Article Altshuler, B Modeling of dose-response relationships. |
title | Modeling of dose-response relationships. |
title_full | Modeling of dose-response relationships. |
title_fullStr | Modeling of dose-response relationships. |
title_full_unstemmed | Modeling of dose-response relationships. |
title_short | Modeling of dose-response relationships. |
title_sort | modeling of dose-response relationships. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568781/ https://www.ncbi.nlm.nih.gov/pubmed/7333256 |
work_keys_str_mv | AT altshulerb modelingofdoseresponserelationships |