Metal-induced infidelity of DNA synthesis.

In this paper, we consider the effects of metal ions on the accuracy of catalysis by DNA polymerases. Certain activating and nonactivating metal ions have been shown to diminish the fidelity of DNA synthesis in vitro with a variety of DNA polymerases. There is a significant correlation between the m...

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Detalles Bibliográficos
Autores principales: Zakour, R A, Kunkel, T A, Loeb, L A
Formato: Texto
Lenguaje:English
Publicado: 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568814/
https://www.ncbi.nlm.nih.gov/pubmed/7274184
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author Zakour, R A
Kunkel, T A
Loeb, L A
author_facet Zakour, R A
Kunkel, T A
Loeb, L A
author_sort Zakour, R A
collection PubMed
description In this paper, we consider the effects of metal ions on the accuracy of catalysis by DNA polymerases. Certain activating and nonactivating metal ions have been shown to diminish the fidelity of DNA synthesis in vitro with a variety of DNA polymerases. There is a significant correlation between the metals that decrease fidelity and those that have been reported to be mutagenic and carcinogenic. Thus, metal carcinogens are no exception to the general postulate that carcinogens can be identified by their interactions with DNA.
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spelling pubmed-15688142006-09-19 Metal-induced infidelity of DNA synthesis. Zakour, R A Kunkel, T A Loeb, L A Environ Health Perspect Research Article In this paper, we consider the effects of metal ions on the accuracy of catalysis by DNA polymerases. Certain activating and nonactivating metal ions have been shown to diminish the fidelity of DNA synthesis in vitro with a variety of DNA polymerases. There is a significant correlation between the metals that decrease fidelity and those that have been reported to be mutagenic and carcinogenic. Thus, metal carcinogens are no exception to the general postulate that carcinogens can be identified by their interactions with DNA. 1981-08 /pmc/articles/PMC1568814/ /pubmed/7274184 Text en
spellingShingle Research Article
Zakour, R A
Kunkel, T A
Loeb, L A
Metal-induced infidelity of DNA synthesis.
title Metal-induced infidelity of DNA synthesis.
title_full Metal-induced infidelity of DNA synthesis.
title_fullStr Metal-induced infidelity of DNA synthesis.
title_full_unstemmed Metal-induced infidelity of DNA synthesis.
title_short Metal-induced infidelity of DNA synthesis.
title_sort metal-induced infidelity of dna synthesis.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568814/
https://www.ncbi.nlm.nih.gov/pubmed/7274184
work_keys_str_mv AT zakourra metalinducedinfidelityofdnasynthesis
AT kunkelta metalinducedinfidelityofdnasynthesis
AT loebla metalinducedinfidelityofdnasynthesis

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