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Observations of the site-specific carcinogenicity of vinyl chloride to humans.

A review of epidemiologic studies of workers exposed to vinyl chloride (VC) was conducted. Some of these studies comprised small cohorts and thus were insensitive in the evaluation of carcinogenic response for sites that do not demonstrate a high relative risk. Other larger studies used methodology...

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Detalles Bibliográficos
Autor principal: Infante, P F
Formato: Texto
Lenguaje:English
Publicado: 1981
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568873/
https://www.ncbi.nlm.nih.gov/pubmed/7199431
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author Infante, P F
author_facet Infante, P F
author_sort Infante, P F
collection PubMed
description A review of epidemiologic studies of workers exposed to vinyl chloride (VC) was conducted. Some of these studies comprised small cohorts and thus were insensitive in the evaluation of carcinogenic response for sites that do not demonstrate a high relative risk. Other larger studies used methodology and design that precluded an interpretation of the results. Such limitations were acknowledged by some authors. Use of restrictive disease rubrics also lead to the submerging of sites that would have demonstrated significant excesses. For example, some investigators analyzed data for liver cancer deaths with the board category of digestive system cancer deaths, while others combined data for CNS cancer deaths with the broad category of "other and unspecified cancer," and most studies analyzed information for lymphatic and hematopoietic system cancer deaths with all data combined. Only four of eight studies reviewed could demonstrate a significant excess of liver cancer among VC-exposed workers--a site confirmed in humans by 1974. In contrast, five of eight studies appear to demonstrate a significant excess of CNS cancer mortality. Workers exposed to VC also demonstrate a significant excess of mortality for lung cancer, while the data for lymphatic and hematopoietic system cancer are suggestive. Interpretation of cancer of the latter systems may have been clarified if investigators had not analyzed their data by broad disease classifications.
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spelling pubmed-15688732006-09-19 Observations of the site-specific carcinogenicity of vinyl chloride to humans. Infante, P F Environ Health Perspect Research Article A review of epidemiologic studies of workers exposed to vinyl chloride (VC) was conducted. Some of these studies comprised small cohorts and thus were insensitive in the evaluation of carcinogenic response for sites that do not demonstrate a high relative risk. Other larger studies used methodology and design that precluded an interpretation of the results. Such limitations were acknowledged by some authors. Use of restrictive disease rubrics also lead to the submerging of sites that would have demonstrated significant excesses. For example, some investigators analyzed data for liver cancer deaths with the board category of digestive system cancer deaths, while others combined data for CNS cancer deaths with the broad category of "other and unspecified cancer," and most studies analyzed information for lymphatic and hematopoietic system cancer deaths with all data combined. Only four of eight studies reviewed could demonstrate a significant excess of liver cancer among VC-exposed workers--a site confirmed in humans by 1974. In contrast, five of eight studies appear to demonstrate a significant excess of CNS cancer mortality. Workers exposed to VC also demonstrate a significant excess of mortality for lung cancer, while the data for lymphatic and hematopoietic system cancer are suggestive. Interpretation of cancer of the latter systems may have been clarified if investigators had not analyzed their data by broad disease classifications. 1981-10 /pmc/articles/PMC1568873/ /pubmed/7199431 Text en
spellingShingle Research Article
Infante, P F
Observations of the site-specific carcinogenicity of vinyl chloride to humans.
title Observations of the site-specific carcinogenicity of vinyl chloride to humans.
title_full Observations of the site-specific carcinogenicity of vinyl chloride to humans.
title_fullStr Observations of the site-specific carcinogenicity of vinyl chloride to humans.
title_full_unstemmed Observations of the site-specific carcinogenicity of vinyl chloride to humans.
title_short Observations of the site-specific carcinogenicity of vinyl chloride to humans.
title_sort observations of the site-specific carcinogenicity of vinyl chloride to humans.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568873/
https://www.ncbi.nlm.nih.gov/pubmed/7199431
work_keys_str_mv AT infantepf observationsofthesitespecificcarcinogenicityofvinylchloridetohumans