New approaches to immunotoxicity testing.

New approaches to immunotoxicity testing are reviewed and discussed. A method of activating T-cells in vivo is presented which circumvents artifacts dur to viability effects encountered with in vitro mitogen assays. The use of adoptive transfer approaches to combine the advantages of in vitro manipu...

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Detalles Bibliográficos
Autor principal: Archer, D L
Formato: Texto
Lenguaje:English
Publicado: 1982
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568879/
https://www.ncbi.nlm.nih.gov/pubmed/7037382
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author Archer, D L
author_facet Archer, D L
author_sort Archer, D L
collection PubMed
description New approaches to immunotoxicity testing are reviewed and discussed. A method of activating T-cells in vivo is presented which circumvents artifacts dur to viability effects encountered with in vitro mitogen assays. The use of adoptive transfer approaches to combine the advantages of in vitro manipulation with in vivo function assays is discussed relative to natural killer cells. The need for an in vitro metabolic activation step coupled to other in vitro immunologic assays is discussed.
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spelling pubmed-15688792006-09-19 New approaches to immunotoxicity testing. Archer, D L Environ Health Perspect Research Article New approaches to immunotoxicity testing are reviewed and discussed. A method of activating T-cells in vivo is presented which circumvents artifacts dur to viability effects encountered with in vitro mitogen assays. The use of adoptive transfer approaches to combine the advantages of in vitro manipulation with in vivo function assays is discussed relative to natural killer cells. The need for an in vitro metabolic activation step coupled to other in vitro immunologic assays is discussed. 1982-02 /pmc/articles/PMC1568879/ /pubmed/7037382 Text en
spellingShingle Research Article
Archer, D L
New approaches to immunotoxicity testing.
title New approaches to immunotoxicity testing.
title_full New approaches to immunotoxicity testing.
title_fullStr New approaches to immunotoxicity testing.
title_full_unstemmed New approaches to immunotoxicity testing.
title_short New approaches to immunotoxicity testing.
title_sort new approaches to immunotoxicity testing.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568879/
https://www.ncbi.nlm.nih.gov/pubmed/7037382
work_keys_str_mv AT archerdl newapproachestoimmunotoxicitytesting

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