Humoral and cell-mediated immune status in mice exposed to chloral hydrate.

Chloral hydrate has been found in our drinking water supplies at levels up to 5 micrograms/1. The purpose of this study was to evaluate the functional status of the immune system in random-bred CD-1 mice exposed to chloral hydrate for 14 and 90 days. Male mice, following 14 or 90 days of exposure to...

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Autores principales: Kauffmann, B M, White, K L, Sanders, V M, Douglas, K A, Sain, L E, Borzelleca, J F, Munson, A E
Formato: Texto
Lenguaje:English
Publicado: 1982
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568978/
https://www.ncbi.nlm.nih.gov/pubmed/6979478
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author Kauffmann, B M
White, K L
Sanders, V M
Douglas, K A
Sain, L E
Borzelleca, J F
Munson, A E
author_facet Kauffmann, B M
White, K L
Sanders, V M
Douglas, K A
Sain, L E
Borzelleca, J F
Munson, A E
author_sort Kauffmann, B M
collection PubMed
description Chloral hydrate has been found in our drinking water supplies at levels up to 5 micrograms/1. The purpose of this study was to evaluate the functional status of the immune system in random-bred CD-1 mice exposed to chloral hydrate for 14 and 90 days. Male mice, following 14 or 90 days of exposure to 1/10 and 1/100 the actual oral LD50, exhibited no alterations in either humoral or cell-mediated immunity. However, female mice exposed for 90 days to chloral hydrate in the drinking water demonstrated a significant depression in humoral immune function. This depression was observed when spleen cells from exposed mice were evaluated for their ability to produce antibody against sheep erythrocytes. These females did not demonstrate any changes in cell-mediated immune status.
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spelling pubmed-15689782006-09-19 Humoral and cell-mediated immune status in mice exposed to chloral hydrate. Kauffmann, B M White, K L Sanders, V M Douglas, K A Sain, L E Borzelleca, J F Munson, A E Environ Health Perspect Research Article Chloral hydrate has been found in our drinking water supplies at levels up to 5 micrograms/1. The purpose of this study was to evaluate the functional status of the immune system in random-bred CD-1 mice exposed to chloral hydrate for 14 and 90 days. Male mice, following 14 or 90 days of exposure to 1/10 and 1/100 the actual oral LD50, exhibited no alterations in either humoral or cell-mediated immunity. However, female mice exposed for 90 days to chloral hydrate in the drinking water demonstrated a significant depression in humoral immune function. This depression was observed when spleen cells from exposed mice were evaluated for their ability to produce antibody against sheep erythrocytes. These females did not demonstrate any changes in cell-mediated immune status. 1982-04 /pmc/articles/PMC1568978/ /pubmed/6979478 Text en
spellingShingle Research Article
Kauffmann, B M
White, K L
Sanders, V M
Douglas, K A
Sain, L E
Borzelleca, J F
Munson, A E
Humoral and cell-mediated immune status in mice exposed to chloral hydrate.
title Humoral and cell-mediated immune status in mice exposed to chloral hydrate.
title_full Humoral and cell-mediated immune status in mice exposed to chloral hydrate.
title_fullStr Humoral and cell-mediated immune status in mice exposed to chloral hydrate.
title_full_unstemmed Humoral and cell-mediated immune status in mice exposed to chloral hydrate.
title_short Humoral and cell-mediated immune status in mice exposed to chloral hydrate.
title_sort humoral and cell-mediated immune status in mice exposed to chloral hydrate.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568978/
https://www.ncbi.nlm.nih.gov/pubmed/6979478
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