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Organic N-chloramines: chemistry and toxicology.

The stability of aqueous solutions of organic N-chloramines, suspected of contaminating chlorinated water, has been studied. Two factors influence the decomposition of solutions of N-chloropiperidine and N-chlorodiethylamine: a spontaneous decomposition and photodecomposition. Since solutions of the...

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Detalles Bibliográficos
Autores principales: Scully, F E, Bempong, M A
Formato: Texto
Lenguaje:English
Publicado: 1982
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569036/
https://www.ncbi.nlm.nih.gov/pubmed/7151751
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author Scully, F E
Bempong, M A
author_facet Scully, F E
Bempong, M A
author_sort Scully, F E
collection PubMed
description The stability of aqueous solutions of organic N-chloramines, suspected of contaminating chlorinated water, has been studied. Two factors influence the decomposition of solutions of N-chloropiperidine and N-chlorodiethylamine: a spontaneous decomposition and photodecomposition. Since solutions of these compounds are relatively long-lived, a need for an analytical method for their identification is discussed. A new method is described which involves reaction of organic N-chloramines with arenesulfinic acid salts. The method gives high yields of stable arenesulfonamides. Several toxicological studies of N-chloropiperidine are described. The compound is mutagenic by Ames assay in Salmonella typhimurium strain TA 100 and does not require metabolic activation as indicated in a total body fluids analysis using C57BL/J6 mice. N-Chloropiperidine was subjected to a modified in vitro cell transformation assay using diploid fibroblast cells from Syrian hamster fetuses. A maximum number of foci of 4 per dish was observed at a seeding of 5 X 10(3) cells/60 mm dish. Under similar conditions, MNNG-induced foci ranged from 4 to 7 per dish.
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spelling pubmed-15690362006-09-19 Organic N-chloramines: chemistry and toxicology. Scully, F E Bempong, M A Environ Health Perspect Research Article The stability of aqueous solutions of organic N-chloramines, suspected of contaminating chlorinated water, has been studied. Two factors influence the decomposition of solutions of N-chloropiperidine and N-chlorodiethylamine: a spontaneous decomposition and photodecomposition. Since solutions of these compounds are relatively long-lived, a need for an analytical method for their identification is discussed. A new method is described which involves reaction of organic N-chloramines with arenesulfinic acid salts. The method gives high yields of stable arenesulfonamides. Several toxicological studies of N-chloropiperidine are described. The compound is mutagenic by Ames assay in Salmonella typhimurium strain TA 100 and does not require metabolic activation as indicated in a total body fluids analysis using C57BL/J6 mice. N-Chloropiperidine was subjected to a modified in vitro cell transformation assay using diploid fibroblast cells from Syrian hamster fetuses. A maximum number of foci of 4 per dish was observed at a seeding of 5 X 10(3) cells/60 mm dish. Under similar conditions, MNNG-induced foci ranged from 4 to 7 per dish. 1982-12 /pmc/articles/PMC1569036/ /pubmed/7151751 Text en
spellingShingle Research Article
Scully, F E
Bempong, M A
Organic N-chloramines: chemistry and toxicology.
title Organic N-chloramines: chemistry and toxicology.
title_full Organic N-chloramines: chemistry and toxicology.
title_fullStr Organic N-chloramines: chemistry and toxicology.
title_full_unstemmed Organic N-chloramines: chemistry and toxicology.
title_short Organic N-chloramines: chemistry and toxicology.
title_sort organic n-chloramines: chemistry and toxicology.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569036/
https://www.ncbi.nlm.nih.gov/pubmed/7151751
work_keys_str_mv AT scullyfe organicnchloramineschemistryandtoxicology
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