In vivo metabolism of 3,2'-dimethyl-4-aminobiphenyl (DMAB) bearing on its organotropism in the Syrian golden hamster and the F344 rat.

The in vivo metabolism of tritiated DMAB was examined in male Syrian golden hamsters, which are susceptible to both urinary bladder and intestinal carcinogenesis by this agent and in male F344 rats in which intestinal tumors represent the main lesions. Evidence was obtained for the presence of the N...

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Detalles Bibliográficos
Autores principales: Nussbaum, M, Fiala, E S, Kulkarni, B, El-Bayoumy, K, Weisburger, J H
Formato: Texto
Lenguaje:English
Publicado: 1983
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569144/
https://www.ncbi.nlm.nih.gov/pubmed/6682032
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author Nussbaum, M
Fiala, E S
Kulkarni, B
El-Bayoumy, K
Weisburger, J H
author_facet Nussbaum, M
Fiala, E S
Kulkarni, B
El-Bayoumy, K
Weisburger, J H
author_sort Nussbaum, M
collection PubMed
description The in vivo metabolism of tritiated DMAB was examined in male Syrian golden hamsters, which are susceptible to both urinary bladder and intestinal carcinogenesis by this agent and in male F344 rats in which intestinal tumors represent the main lesions. Evidence was obtained for the presence of the N-hydroxy-N-glucuronide of DMAB as a major metabolite in hamster urine and bile and in rat bile but not urine. The routes of excretion of this metabolite, which may represent a transport form of the ultimate carcinogen, correlate well with the main tumor sites in the two species. Other metabolites partially identified were the sulfates and glucuronides of C-hydroxylated DMAB and C-hydroxylated-N-acetyl DMAB.
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spelling pubmed-15691442006-09-18 In vivo metabolism of 3,2'-dimethyl-4-aminobiphenyl (DMAB) bearing on its organotropism in the Syrian golden hamster and the F344 rat. Nussbaum, M Fiala, E S Kulkarni, B El-Bayoumy, K Weisburger, J H Environ Health Perspect Research Article The in vivo metabolism of tritiated DMAB was examined in male Syrian golden hamsters, which are susceptible to both urinary bladder and intestinal carcinogenesis by this agent and in male F344 rats in which intestinal tumors represent the main lesions. Evidence was obtained for the presence of the N-hydroxy-N-glucuronide of DMAB as a major metabolite in hamster urine and bile and in rat bile but not urine. The routes of excretion of this metabolite, which may represent a transport form of the ultimate carcinogen, correlate well with the main tumor sites in the two species. Other metabolites partially identified were the sulfates and glucuronides of C-hydroxylated DMAB and C-hydroxylated-N-acetyl DMAB. 1983-03 /pmc/articles/PMC1569144/ /pubmed/6682032 Text en
spellingShingle Research Article
Nussbaum, M
Fiala, E S
Kulkarni, B
El-Bayoumy, K
Weisburger, J H
In vivo metabolism of 3,2'-dimethyl-4-aminobiphenyl (DMAB) bearing on its organotropism in the Syrian golden hamster and the F344 rat.
title In vivo metabolism of 3,2'-dimethyl-4-aminobiphenyl (DMAB) bearing on its organotropism in the Syrian golden hamster and the F344 rat.
title_full In vivo metabolism of 3,2'-dimethyl-4-aminobiphenyl (DMAB) bearing on its organotropism in the Syrian golden hamster and the F344 rat.
title_fullStr In vivo metabolism of 3,2'-dimethyl-4-aminobiphenyl (DMAB) bearing on its organotropism in the Syrian golden hamster and the F344 rat.
title_full_unstemmed In vivo metabolism of 3,2'-dimethyl-4-aminobiphenyl (DMAB) bearing on its organotropism in the Syrian golden hamster and the F344 rat.
title_short In vivo metabolism of 3,2'-dimethyl-4-aminobiphenyl (DMAB) bearing on its organotropism in the Syrian golden hamster and the F344 rat.
title_sort in vivo metabolism of 3,2'-dimethyl-4-aminobiphenyl (dmab) bearing on its organotropism in the syrian golden hamster and the f344 rat.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569144/
https://www.ncbi.nlm.nih.gov/pubmed/6682032
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