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Genotoxic effects of 2-acetylaminofluorene on rat and human hepatocytes.

Isolated rat and human hepatocytes in primary culture were shown to metabolize AAF to reactive intermediates which damaged hepatocyte DNA. A significant increase in unscheduled DNA synthesis was detectable by autoradiography in rat and human hepatocytes exposed to concentrations of AAF as low as 1 m...

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Detalles Bibliográficos
Autores principales:	Strom, S C, Jirtle, R L, Michalopoulos, G
Formato:	Texto
Lenguaje:	English
Publicado:	1983
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569146/ https://www.ncbi.nlm.nih.gov/pubmed/6832090

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