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Tumor enhancers: underestimated factors in the epidemiology of lifestyle-associated cancers.

Model studies in carcinogenesis give ample evidence of synergistic, tumor-promoting and cocarcinogenic effects of environmental agents and dietary factors in regard to the induction and propagation of neoplasms. This presentation examines tumor enhancers deriving from the use of tobacco and alcohol...

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Detalles Bibliográficos
Autor principal: Wynder, E L
Formato: Texto
Lenguaje:English
Publicado: 1983
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569235/
https://www.ncbi.nlm.nih.gov/pubmed/6873011
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author Wynder, E L
author_facet Wynder, E L
author_sort Wynder, E L
collection PubMed
description Model studies in carcinogenesis give ample evidence of synergistic, tumor-promoting and cocarcinogenic effects of environmental agents and dietary factors in regard to the induction and propagation of neoplasms. This presentation examines tumor enhancers deriving from the use of tobacco and alcohol as well as the effects of dietary fat and other food components on endocrinological and gastrointestinal factors that contribute to tumor development in the breast and colon. It is suggested that epidemiologic surveys need to intensify investigations on the interrelationship of tumor enhancers and genotoxic agents in high risk populations and that they need to study especially the dose-response effects of such agents. Experimental studies should focus increasingly on epidemiologic leads that suggest potential enhancers of genotoxic agents and should delineate mechanisms involved in such multistep carcinogenesis processes. This approach would be a prerequisite for chemoprevention. Recommendations for changes of lifestyle habits and practical approaches towards reduction of tumor enhancers in consumer goods and in the environment are additional requirements for appropriate preventive strategies.
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spelling pubmed-15692352006-09-18 Tumor enhancers: underestimated factors in the epidemiology of lifestyle-associated cancers. Wynder, E L Environ Health Perspect Research Article Model studies in carcinogenesis give ample evidence of synergistic, tumor-promoting and cocarcinogenic effects of environmental agents and dietary factors in regard to the induction and propagation of neoplasms. This presentation examines tumor enhancers deriving from the use of tobacco and alcohol as well as the effects of dietary fat and other food components on endocrinological and gastrointestinal factors that contribute to tumor development in the breast and colon. It is suggested that epidemiologic surveys need to intensify investigations on the interrelationship of tumor enhancers and genotoxic agents in high risk populations and that they need to study especially the dose-response effects of such agents. Experimental studies should focus increasingly on epidemiologic leads that suggest potential enhancers of genotoxic agents and should delineate mechanisms involved in such multistep carcinogenesis processes. This approach would be a prerequisite for chemoprevention. Recommendations for changes of lifestyle habits and practical approaches towards reduction of tumor enhancers in consumer goods and in the environment are additional requirements for appropriate preventive strategies. 1983-04 /pmc/articles/PMC1569235/ /pubmed/6873011 Text en
spellingShingle Research Article
Wynder, E L
Tumor enhancers: underestimated factors in the epidemiology of lifestyle-associated cancers.
title Tumor enhancers: underestimated factors in the epidemiology of lifestyle-associated cancers.
title_full Tumor enhancers: underestimated factors in the epidemiology of lifestyle-associated cancers.
title_fullStr Tumor enhancers: underestimated factors in the epidemiology of lifestyle-associated cancers.
title_full_unstemmed Tumor enhancers: underestimated factors in the epidemiology of lifestyle-associated cancers.
title_short Tumor enhancers: underestimated factors in the epidemiology of lifestyle-associated cancers.
title_sort tumor enhancers: underestimated factors in the epidemiology of lifestyle-associated cancers.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569235/
https://www.ncbi.nlm.nih.gov/pubmed/6873011
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