Factors involved in the cytotoxicity of kaolinite towards macrophages in vitro.

The cytotoxicity of a high purity Cornish kaolinite toward mouse peritoneal macrophages in vitro was examined. The material was cytotoxic towards these cells, the activity could be decreased substantially by pretreating the dust with poly(2-vinylpyridine N-oxide). Pretreatment of the dusts with poly...

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Detalles Bibliográficos
Autor principal: Davies, R
Formato: Texto
Lenguaje:English
Publicado: 1983
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569275/
https://www.ncbi.nlm.nih.gov/pubmed/6641658
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author Davies, R
author_facet Davies, R
author_sort Davies, R
collection PubMed
description The cytotoxicity of a high purity Cornish kaolinite toward mouse peritoneal macrophages in vitro was examined. The material was cytotoxic towards these cells, the activity could be decreased substantially by pretreating the dust with poly(2-vinylpyridine N-oxide). Pretreatment of the dusts with poly(acrylic acid) had a small effect on cytotoxicity, but combinations of the polymer treatments virtually abolished the material's biological activity towards macrophages. These studies indicated that the cytotoxicity of kaolinite is not due to its flakelike morphology.
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spelling pubmed-15692752006-09-18 Factors involved in the cytotoxicity of kaolinite towards macrophages in vitro. Davies, R Environ Health Perspect Research Article The cytotoxicity of a high purity Cornish kaolinite toward mouse peritoneal macrophages in vitro was examined. The material was cytotoxic towards these cells, the activity could be decreased substantially by pretreating the dust with poly(2-vinylpyridine N-oxide). Pretreatment of the dusts with poly(acrylic acid) had a small effect on cytotoxicity, but combinations of the polymer treatments virtually abolished the material's biological activity towards macrophages. These studies indicated that the cytotoxicity of kaolinite is not due to its flakelike morphology. 1983-09 /pmc/articles/PMC1569275/ /pubmed/6641658 Text en
spellingShingle Research Article
Davies, R
Factors involved in the cytotoxicity of kaolinite towards macrophages in vitro.
title Factors involved in the cytotoxicity of kaolinite towards macrophages in vitro.
title_full Factors involved in the cytotoxicity of kaolinite towards macrophages in vitro.
title_fullStr Factors involved in the cytotoxicity of kaolinite towards macrophages in vitro.
title_full_unstemmed Factors involved in the cytotoxicity of kaolinite towards macrophages in vitro.
title_short Factors involved in the cytotoxicity of kaolinite towards macrophages in vitro.
title_sort factors involved in the cytotoxicity of kaolinite towards macrophages in vitro.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569275/
https://www.ncbi.nlm.nih.gov/pubmed/6641658
work_keys_str_mv AT daviesr factorsinvolvedinthecytotoxicityofkaolinitetowardsmacrophagesinvitro

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