Asbestos affects the in vitro uptake and detoxification of aromatic compounds.

A number of mineral dusts were tested for their ability to catalyze the transformation of benzo(a)pyrene from the microcrystalline state into lipid solution. The findings of Lakowicz and his co-workers, that fibrous dusts were more active than nonfibrous dusts, were confirmed. Macromolecular binding...

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Detalles Bibliográficos
Autores principales: Brown, R C, Fleming, G T, Knight, A I
Formato: Texto
Lenguaje:English
Publicado: 1983
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569283/
https://www.ncbi.nlm.nih.gov/pubmed/6315373
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author Brown, R C
Fleming, G T
Knight, A I
author_facet Brown, R C
Fleming, G T
Knight, A I
author_sort Brown, R C
collection PubMed
description A number of mineral dusts were tested for their ability to catalyze the transformation of benzo(a)pyrene from the microcrystalline state into lipid solution. The findings of Lakowicz and his co-workers, that fibrous dusts were more active than nonfibrous dusts, were confirmed. Macromolecular binding metabolites of BaP were formed in A549 cells to a similar extent whether the BaP was added in solution or adsorbed to fibers; however, the level of water-soluble metabolites was lower in cultures treated with adsorbed hydrocarbon. It was found that asbestos can also inhibit the accumulation of 1-naphthyl glucuronide in cultures treated with 1-naphthol. The significance of this in asbestos pathogenesis is briefly discussed.
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spelling pubmed-15692832006-09-18 Asbestos affects the in vitro uptake and detoxification of aromatic compounds. Brown, R C Fleming, G T Knight, A I Environ Health Perspect Research Article A number of mineral dusts were tested for their ability to catalyze the transformation of benzo(a)pyrene from the microcrystalline state into lipid solution. The findings of Lakowicz and his co-workers, that fibrous dusts were more active than nonfibrous dusts, were confirmed. Macromolecular binding metabolites of BaP were formed in A549 cells to a similar extent whether the BaP was added in solution or adsorbed to fibers; however, the level of water-soluble metabolites was lower in cultures treated with adsorbed hydrocarbon. It was found that asbestos can also inhibit the accumulation of 1-naphthyl glucuronide in cultures treated with 1-naphthol. The significance of this in asbestos pathogenesis is briefly discussed. 1983-09 /pmc/articles/PMC1569283/ /pubmed/6315373 Text en
spellingShingle Research Article
Brown, R C
Fleming, G T
Knight, A I
Asbestos affects the in vitro uptake and detoxification of aromatic compounds.
title Asbestos affects the in vitro uptake and detoxification of aromatic compounds.
title_full Asbestos affects the in vitro uptake and detoxification of aromatic compounds.
title_fullStr Asbestos affects the in vitro uptake and detoxification of aromatic compounds.
title_full_unstemmed Asbestos affects the in vitro uptake and detoxification of aromatic compounds.
title_short Asbestos affects the in vitro uptake and detoxification of aromatic compounds.
title_sort asbestos affects the in vitro uptake and detoxification of aromatic compounds.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569283/
https://www.ncbi.nlm.nih.gov/pubmed/6315373
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