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Extrapolation of animal carcinogenicity data: limitations and pitfalls.

Laboratory-generated animal bioassay data often serve as the basis for estimating potential human cancer risk. However, there is no single procedure that has been universally accepted as the method of choice for extrapolating experimentally observed results to the low exposure levels that are genera...

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Detalles Bibliográficos
Autor principal: Hogan, M D
Formato: Texto
Lenguaje:English
Publicado: 1983
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569384/
https://www.ncbi.nlm.nih.gov/pubmed/6825619
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author Hogan, M D
author_facet Hogan, M D
author_sort Hogan, M D
collection PubMed
description Laboratory-generated animal bioassay data often serve as the basis for estimating potential human cancer risk. However, there is no single procedure that has been universally accepted as the method of choice for extrapolating experimentally observed results to the low exposure levels that are generally of public health concern. All of the models proposed to date suffer from various limitations. Therefore, the most prudent approach may be to rely primarily on the more conservative procedures such as linear extrapolation until a better understanding of the biological mechanisms underlying the process of carcinogenesis is attained. In addition to the choice of an extrapolation model, there are a variety of other factors, such as the incorporation of background cancer rates, the potential for synergistic reactions, differential pharmacokinetic effects and differences in exposure regimen, that can have a significant bearing on the extrapolation of animal carcinogenicity data to man.
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spelling pubmed-15693842006-09-18 Extrapolation of animal carcinogenicity data: limitations and pitfalls. Hogan, M D Environ Health Perspect Research Article Laboratory-generated animal bioassay data often serve as the basis for estimating potential human cancer risk. However, there is no single procedure that has been universally accepted as the method of choice for extrapolating experimentally observed results to the low exposure levels that are generally of public health concern. All of the models proposed to date suffer from various limitations. Therefore, the most prudent approach may be to rely primarily on the more conservative procedures such as linear extrapolation until a better understanding of the biological mechanisms underlying the process of carcinogenesis is attained. In addition to the choice of an extrapolation model, there are a variety of other factors, such as the incorporation of background cancer rates, the potential for synergistic reactions, differential pharmacokinetic effects and differences in exposure regimen, that can have a significant bearing on the extrapolation of animal carcinogenicity data to man. 1983-01 /pmc/articles/PMC1569384/ /pubmed/6825619 Text en
spellingShingle Research Article
Hogan, M D
Extrapolation of animal carcinogenicity data: limitations and pitfalls.
title Extrapolation of animal carcinogenicity data: limitations and pitfalls.
title_full Extrapolation of animal carcinogenicity data: limitations and pitfalls.
title_fullStr Extrapolation of animal carcinogenicity data: limitations and pitfalls.
title_full_unstemmed Extrapolation of animal carcinogenicity data: limitations and pitfalls.
title_short Extrapolation of animal carcinogenicity data: limitations and pitfalls.
title_sort extrapolation of animal carcinogenicity data: limitations and pitfalls.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569384/
https://www.ncbi.nlm.nih.gov/pubmed/6825619
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