Specific down-regulation of XIAP with RNA interference enhances the sensitivity of canine tumor cell-lines to TRAIL and doxorubicin

BACKGROUND: Apoptosis resistance occurs in various tumors. The anti-apoptotic XIAP protein is responsible for inhibiting apoptosis by reducing caspase-3 activation. Our aim is to evaluate whether RNA inhibition against XIAP increases the sensitivity of canine cell-lines for chemotherapeutics such as...

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Detalles Bibliográficos
Autores principales: Spee, Bart, Jonkers, Martijn DB, Arends, Brigitte, Rutteman, Gerard R, Rothuizen, Jan, Penning, Louis C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569868/
https://www.ncbi.nlm.nih.gov/pubmed/16953886
http://dx.doi.org/10.1186/1476-4598-5-34

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569868/
https://www.ncbi.nlm.nih.gov/pubmed/16953886
http://dx.doi.org/10.1186/1476-4598-5-34

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