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Lung Cancer Attributable to Indoor Radon Exposure in France: Impact of the Risk Models and Uncertainty Analysis
OBJECTIVE: The inhalation of radon, a well-established human carcinogen, is the principal—and omnipresent—source of radioactivity exposure for the general population of most countries. Scientists have thus sought to assess the lung cancer risk associated with indoor radon. Our aim here is to assess...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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National Institute of Environmental Health Sciences
2006
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570096/ https://www.ncbi.nlm.nih.gov/pubmed/16966089 http://dx.doi.org/10.1289/ehp.9070 |
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author | Catelinois, Olivier Rogel, Agnès Laurier, Dominique Billon, Solenne Hemon, Denis Verger, Pierre Tirmarche, Margot |
author_facet | Catelinois, Olivier Rogel, Agnès Laurier, Dominique Billon, Solenne Hemon, Denis Verger, Pierre Tirmarche, Margot |
author_sort | Catelinois, Olivier |
collection | PubMed |
description | OBJECTIVE: The inhalation of radon, a well-established human carcinogen, is the principal—and omnipresent—source of radioactivity exposure for the general population of most countries. Scientists have thus sought to assess the lung cancer risk associated with indoor radon. Our aim here is to assess this risk in France, using all available epidemiologic results and performing an uncertainty analysis. METHODS: We examined the exposure–response relations derived from cohorts of miners and from joint analyses of residential case-control studies and considered the interaction between radon and tobacco. The exposure data come from measurement campaigns conducted since the beginning of the 1980s by the Institute for Radiation Protection and Nuclear Safety and the Directorate-General of Health in France. We quantified the uncertainties associated with risk coefficients and exposures and calculated their impact on risk estimates. RESULTS: The estimated number of lung cancer deaths attributable to indoor radon exposure ranges from 543 [90% uncertainty interval (UI), 75–1,097] to 3,108 (90% UI, 2,996–3,221), depending on the model considered. This calculation suggests that from 2.2% (90% UI, 0.3–4.4) to 12.4% (90% UI, 11.9–12.8) of these deaths in France may be attributable to indoor radon. DISCUSSION: In this original work we used different exposure–response relations from several epidemiologic studies and found that regardless of the relation chosen, the number of lung cancer deaths attributable to indoor radon appears relatively stable. Smokers can reduce their risk not only by reducing their indoor radon concentration but also by giving up smoking. |
format | Text |
id | pubmed-1570096 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-15700962006-09-25 Lung Cancer Attributable to Indoor Radon Exposure in France: Impact of the Risk Models and Uncertainty Analysis Catelinois, Olivier Rogel, Agnès Laurier, Dominique Billon, Solenne Hemon, Denis Verger, Pierre Tirmarche, Margot Environ Health Perspect Research OBJECTIVE: The inhalation of radon, a well-established human carcinogen, is the principal—and omnipresent—source of radioactivity exposure for the general population of most countries. Scientists have thus sought to assess the lung cancer risk associated with indoor radon. Our aim here is to assess this risk in France, using all available epidemiologic results and performing an uncertainty analysis. METHODS: We examined the exposure–response relations derived from cohorts of miners and from joint analyses of residential case-control studies and considered the interaction between radon and tobacco. The exposure data come from measurement campaigns conducted since the beginning of the 1980s by the Institute for Radiation Protection and Nuclear Safety and the Directorate-General of Health in France. We quantified the uncertainties associated with risk coefficients and exposures and calculated their impact on risk estimates. RESULTS: The estimated number of lung cancer deaths attributable to indoor radon exposure ranges from 543 [90% uncertainty interval (UI), 75–1,097] to 3,108 (90% UI, 2,996–3,221), depending on the model considered. This calculation suggests that from 2.2% (90% UI, 0.3–4.4) to 12.4% (90% UI, 11.9–12.8) of these deaths in France may be attributable to indoor radon. DISCUSSION: In this original work we used different exposure–response relations from several epidemiologic studies and found that regardless of the relation chosen, the number of lung cancer deaths attributable to indoor radon appears relatively stable. Smokers can reduce their risk not only by reducing their indoor radon concentration but also by giving up smoking. National Institute of Environmental Health Sciences 2006-09 2006-05-30 /pmc/articles/PMC1570096/ /pubmed/16966089 http://dx.doi.org/10.1289/ehp.9070 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research Catelinois, Olivier Rogel, Agnès Laurier, Dominique Billon, Solenne Hemon, Denis Verger, Pierre Tirmarche, Margot Lung Cancer Attributable to Indoor Radon Exposure in France: Impact of the Risk Models and Uncertainty Analysis |
title | Lung Cancer Attributable to Indoor Radon Exposure in France: Impact of the Risk Models and Uncertainty Analysis |
title_full | Lung Cancer Attributable to Indoor Radon Exposure in France: Impact of the Risk Models and Uncertainty Analysis |
title_fullStr | Lung Cancer Attributable to Indoor Radon Exposure in France: Impact of the Risk Models and Uncertainty Analysis |
title_full_unstemmed | Lung Cancer Attributable to Indoor Radon Exposure in France: Impact of the Risk Models and Uncertainty Analysis |
title_short | Lung Cancer Attributable to Indoor Radon Exposure in France: Impact of the Risk Models and Uncertainty Analysis |
title_sort | lung cancer attributable to indoor radon exposure in france: impact of the risk models and uncertainty analysis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570096/ https://www.ncbi.nlm.nih.gov/pubmed/16966089 http://dx.doi.org/10.1289/ehp.9070 |
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