Intricate Knots in Proteins: Function and Evolution

Our investigation of knotted structures in the Protein Data Bank reveals the most complicated knot discovered to date. We suggest that the occurrence of this knot in a human ubiquitin hydrolase might be related to the role of the enzyme in protein degradation. While knots are usually preserved among...

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Detalles Bibliográficos
Autores principales: Virnau, Peter, A. Mirny, Leonid, Kardar, Mehran
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570178/
https://www.ncbi.nlm.nih.gov/pubmed/16978047
http://dx.doi.org/10.1371/journal.pcbi.0020122
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author Virnau, Peter
A. Mirny, Leonid
Kardar, Mehran
author_facet Virnau, Peter
A. Mirny, Leonid
Kardar, Mehran
author_sort Virnau, Peter
collection PubMed
description Our investigation of knotted structures in the Protein Data Bank reveals the most complicated knot discovered to date. We suggest that the occurrence of this knot in a human ubiquitin hydrolase might be related to the role of the enzyme in protein degradation. While knots are usually preserved among homologues, we also identify an exception in a transcarbamylase. This allows us to exemplify the function of knots in proteins and to suggest how they may have been created.
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spelling pubmed-15701782006-10-06 Intricate Knots in Proteins: Function and Evolution Virnau, Peter A. Mirny, Leonid Kardar, Mehran PLoS Comput Biol Research Article Our investigation of knotted structures in the Protein Data Bank reveals the most complicated knot discovered to date. We suggest that the occurrence of this knot in a human ubiquitin hydrolase might be related to the role of the enzyme in protein degradation. While knots are usually preserved among homologues, we also identify an exception in a transcarbamylase. This allows us to exemplify the function of knots in proteins and to suggest how they may have been created. Public Library of Science 2006-09 2006-09-15 /pmc/articles/PMC1570178/ /pubmed/16978047 http://dx.doi.org/10.1371/journal.pcbi.0020122 Text en © 2006 Virnau et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Virnau, Peter
A. Mirny, Leonid
Kardar, Mehran
Intricate Knots in Proteins: Function and Evolution
title Intricate Knots in Proteins: Function and Evolution
title_full Intricate Knots in Proteins: Function and Evolution
title_fullStr Intricate Knots in Proteins: Function and Evolution
title_full_unstemmed Intricate Knots in Proteins: Function and Evolution
title_short Intricate Knots in Proteins: Function and Evolution
title_sort intricate knots in proteins: function and evolution
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570178/
https://www.ncbi.nlm.nih.gov/pubmed/16978047
http://dx.doi.org/10.1371/journal.pcbi.0020122
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