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Long-term changes of serum chemokine levels in vaccinated military personnel
BACKGROUND: Members of the United States Armed Forces receive a series of vaccinations during their course of service. To investigate the influence of multiple vaccinations on innate immunity, we measured concentrations of a panel of immunomodulatory and pro-inflammatory cytokines in serum samples f...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1578581/ https://www.ncbi.nlm.nih.gov/pubmed/16965634 http://dx.doi.org/10.1186/1471-2172-7-21 |
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author | Brichacek, Beda Vanpouille, Christophe Trachtenberg, Alexander J Pushkarsky, Tatiana Dubrovsky, Larisa Martin, Gregory Simon, Gary Bukrinsky, Michael |
author_facet | Brichacek, Beda Vanpouille, Christophe Trachtenberg, Alexander J Pushkarsky, Tatiana Dubrovsky, Larisa Martin, Gregory Simon, Gary Bukrinsky, Michael |
author_sort | Brichacek, Beda |
collection | PubMed |
description | BACKGROUND: Members of the United States Armed Forces receive a series of vaccinations during their course of service. To investigate the influence of multiple vaccinations on innate immunity, we measured concentrations of a panel of immunomodulatory and pro-inflammatory cytokines in serum samples from a group of such individuals. RESULTS: Significantly increased levels of macrophage inflammatory protein 1α (MIP-1α), MIP-1β and interleukin 8 (IL-8) were detected. Since these cytokines are known to have anti-human immunodeficiency virus (HIV) activity, we tested the effect of serum from these individuals on HIV-1 infectivity and susceptibility of their peripheral blood mononuclear cells (PBMCs) to HIV-1 infection in vitro. Sera from vaccinated military personnel inhibited, and their PBMCs were partially resistant to, infection by HIV-1 strains tropic to CCR5 (R5), but not to CXCR4 (X4), chemokine receptor. CONCLUSION: These findings demonstrate that increased anti-HIV chemokines can be detected in vaccine recipients up to 68 weeks following immunization. |
format | Text |
id | pubmed-1578581 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-15785812006-09-27 Long-term changes of serum chemokine levels in vaccinated military personnel Brichacek, Beda Vanpouille, Christophe Trachtenberg, Alexander J Pushkarsky, Tatiana Dubrovsky, Larisa Martin, Gregory Simon, Gary Bukrinsky, Michael BMC Immunol Research Article BACKGROUND: Members of the United States Armed Forces receive a series of vaccinations during their course of service. To investigate the influence of multiple vaccinations on innate immunity, we measured concentrations of a panel of immunomodulatory and pro-inflammatory cytokines in serum samples from a group of such individuals. RESULTS: Significantly increased levels of macrophage inflammatory protein 1α (MIP-1α), MIP-1β and interleukin 8 (IL-8) were detected. Since these cytokines are known to have anti-human immunodeficiency virus (HIV) activity, we tested the effect of serum from these individuals on HIV-1 infectivity and susceptibility of their peripheral blood mononuclear cells (PBMCs) to HIV-1 infection in vitro. Sera from vaccinated military personnel inhibited, and their PBMCs were partially resistant to, infection by HIV-1 strains tropic to CCR5 (R5), but not to CXCR4 (X4), chemokine receptor. CONCLUSION: These findings demonstrate that increased anti-HIV chemokines can be detected in vaccine recipients up to 68 weeks following immunization. BioMed Central 2006-09-11 /pmc/articles/PMC1578581/ /pubmed/16965634 http://dx.doi.org/10.1186/1471-2172-7-21 Text en Copyright © 2006 Brichacek et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Brichacek, Beda Vanpouille, Christophe Trachtenberg, Alexander J Pushkarsky, Tatiana Dubrovsky, Larisa Martin, Gregory Simon, Gary Bukrinsky, Michael Long-term changes of serum chemokine levels in vaccinated military personnel |
title | Long-term changes of serum chemokine levels in vaccinated military personnel |
title_full | Long-term changes of serum chemokine levels in vaccinated military personnel |
title_fullStr | Long-term changes of serum chemokine levels in vaccinated military personnel |
title_full_unstemmed | Long-term changes of serum chemokine levels in vaccinated military personnel |
title_short | Long-term changes of serum chemokine levels in vaccinated military personnel |
title_sort | long-term changes of serum chemokine levels in vaccinated military personnel |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1578581/ https://www.ncbi.nlm.nih.gov/pubmed/16965634 http://dx.doi.org/10.1186/1471-2172-7-21 |
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