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Heritability and major gene effects on left ventricular mass in the Chinese population: a family study

BACKGROUND: Genetic components controlling for echocardiographically determined left ventricular (LV) mass are still unclear in the Chinese population. METHODS: We conducted a family study from the Chin-San community, Taiwan, and a total of 368 families, 1145 subjects, were recruited to undergo echo...

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Autores principales: Chien, Kuo-Liong, Hsu, Hsiu-Ching, Su, Ta-Chen, Chen, Ming-Fong, Lee, Yuan-Teh
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1579230/
https://www.ncbi.nlm.nih.gov/pubmed/16945138
http://dx.doi.org/10.1186/1471-2261-6-37
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author Chien, Kuo-Liong
Hsu, Hsiu-Ching
Su, Ta-Chen
Chen, Ming-Fong
Lee, Yuan-Teh
author_facet Chien, Kuo-Liong
Hsu, Hsiu-Ching
Su, Ta-Chen
Chen, Ming-Fong
Lee, Yuan-Teh
author_sort Chien, Kuo-Liong
collection PubMed
description BACKGROUND: Genetic components controlling for echocardiographically determined left ventricular (LV) mass are still unclear in the Chinese population. METHODS: We conducted a family study from the Chin-San community, Taiwan, and a total of 368 families, 1145 subjects, were recruited to undergo echocardiography to measure LV mass. Commingling analysis, familial correlation, and complex segregation analysis were applied to detect component distributions and the mode of inheritance. RESULTS: The two-component distribution model was the best-fitting model to describe the distribution of LV mass. The highest familial correlation coefficients were mother-son (0.379, P < .0001) and father-son (0.356, P < .0001). Genetic heritability (h(2)) of LV mass was estimated as 0.268 ± 0.061 (P < .0001); it decreased to 0.153 ± 0.052 (P = .0009) after systolic blood pressure adjustment. Major gene effects with polygenic components were the best-fitting model to explain the inheritance mode of LV mass. The estimated allele frequency of the gene was 0.089. CONCLUSION: There were significant familial correlations, heritability and a major gene effect on LV mass in the population-based families.
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spelling pubmed-15792302006-09-28 Heritability and major gene effects on left ventricular mass in the Chinese population: a family study Chien, Kuo-Liong Hsu, Hsiu-Ching Su, Ta-Chen Chen, Ming-Fong Lee, Yuan-Teh BMC Cardiovasc Disord Research Article BACKGROUND: Genetic components controlling for echocardiographically determined left ventricular (LV) mass are still unclear in the Chinese population. METHODS: We conducted a family study from the Chin-San community, Taiwan, and a total of 368 families, 1145 subjects, were recruited to undergo echocardiography to measure LV mass. Commingling analysis, familial correlation, and complex segregation analysis were applied to detect component distributions and the mode of inheritance. RESULTS: The two-component distribution model was the best-fitting model to describe the distribution of LV mass. The highest familial correlation coefficients were mother-son (0.379, P < .0001) and father-son (0.356, P < .0001). Genetic heritability (h(2)) of LV mass was estimated as 0.268 ± 0.061 (P < .0001); it decreased to 0.153 ± 0.052 (P = .0009) after systolic blood pressure adjustment. Major gene effects with polygenic components were the best-fitting model to explain the inheritance mode of LV mass. The estimated allele frequency of the gene was 0.089. CONCLUSION: There were significant familial correlations, heritability and a major gene effect on LV mass in the population-based families. BioMed Central 2006-08-31 /pmc/articles/PMC1579230/ /pubmed/16945138 http://dx.doi.org/10.1186/1471-2261-6-37 Text en Copyright © 2006 Chien et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chien, Kuo-Liong
Hsu, Hsiu-Ching
Su, Ta-Chen
Chen, Ming-Fong
Lee, Yuan-Teh
Heritability and major gene effects on left ventricular mass in the Chinese population: a family study
title Heritability and major gene effects on left ventricular mass in the Chinese population: a family study
title_full Heritability and major gene effects on left ventricular mass in the Chinese population: a family study
title_fullStr Heritability and major gene effects on left ventricular mass in the Chinese population: a family study
title_full_unstemmed Heritability and major gene effects on left ventricular mass in the Chinese population: a family study
title_short Heritability and major gene effects on left ventricular mass in the Chinese population: a family study
title_sort heritability and major gene effects on left ventricular mass in the chinese population: a family study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1579230/
https://www.ncbi.nlm.nih.gov/pubmed/16945138
http://dx.doi.org/10.1186/1471-2261-6-37
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