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Acquisition and Elimination of Bacterial Vaginosis During Pregnancy: A Danish Population-Based Study

Objectives: the aim was to examine factors associated with acquisition and elimination of bacterial vaginosis in pregnancy. Methods: a group of 229 pregnant women were randomly selected from a population-based prospective cohort study of 2927. They were examined at enrollment (mean gestational weeks...

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Autores principales: Vogel, Ida, Thorsen, Poul, Jeune, Bernard, Jacobsson, Bo, Ebbesen, Niels, Arpi, Magnus, Bremmelgaard, Annie, Møller, Birger R.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1581474/
https://www.ncbi.nlm.nih.gov/pubmed/17485815
http://dx.doi.org/10.1155/IDOG/2006/94646
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author Vogel, Ida
Thorsen, Poul
Jeune, Bernard
Jacobsson, Bo
Ebbesen, Niels
Arpi, Magnus
Bremmelgaard, Annie
Møller, Birger R.
author_facet Vogel, Ida
Thorsen, Poul
Jeune, Bernard
Jacobsson, Bo
Ebbesen, Niels
Arpi, Magnus
Bremmelgaard, Annie
Møller, Birger R.
author_sort Vogel, Ida
collection PubMed
description Objectives: the aim was to examine factors associated with acquisition and elimination of bacterial vaginosis in pregnancy. Methods: a group of 229 pregnant women were randomly selected from a population-based prospective cohort study of 2927. They were examined at enrollment (mean gestational weeks 16w + 0d) and again in mid-third trimester (mean gestational age 32w + 3d). Measures: BV (Amsel's clinical criteria), microbiological cultures of the genital tract and questionnaire data. Results: BV prevalence decreased from 17% in early second trimester to 14% in mid-third trimester due to a tenfold higher elimination rate (39%) than incidence rate (4%). Heavy smokers (> 10/d) in early pregnancy were at increased risk (5.3 [1.1–25]) for the acquisition of BV during pregnancy, as were women receiving public benefits (4.8 [1.0–22]), having a vaginal pH above 4.5 (6.3 [1.4–29]) or vaginal anaerobe bacteria (18 [2.7–122]) at enrollment. A previous use of combined oral contraceptives was preventive for the acquisition of BV (0.2 [0.03–0.96]). Elimination of BV in pregnancy tended to be associated with a heavy growth of Lactobacillus (3.2 [0.8–13]) at enrollment. Conclusions: acquisition of BV during pregnancy is rare and is associated with smoking, while the presence of anaerobe bacteria and a vaginal pH > 4.5 are interpreted as steps on a gradual change towards BV. In the same way heavy growth of Lactobacillus spp in early pregnancy may be an indicator of women on the way to eliminate BV.
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spelling pubmed-15814742006-10-11 Acquisition and Elimination of Bacterial Vaginosis During Pregnancy: A Danish Population-Based Study Vogel, Ida Thorsen, Poul Jeune, Bernard Jacobsson, Bo Ebbesen, Niels Arpi, Magnus Bremmelgaard, Annie Møller, Birger R. Infect Dis Obstet Gynecol Clinical Study Objectives: the aim was to examine factors associated with acquisition and elimination of bacterial vaginosis in pregnancy. Methods: a group of 229 pregnant women were randomly selected from a population-based prospective cohort study of 2927. They were examined at enrollment (mean gestational weeks 16w + 0d) and again in mid-third trimester (mean gestational age 32w + 3d). Measures: BV (Amsel's clinical criteria), microbiological cultures of the genital tract and questionnaire data. Results: BV prevalence decreased from 17% in early second trimester to 14% in mid-third trimester due to a tenfold higher elimination rate (39%) than incidence rate (4%). Heavy smokers (> 10/d) in early pregnancy were at increased risk (5.3 [1.1–25]) for the acquisition of BV during pregnancy, as were women receiving public benefits (4.8 [1.0–22]), having a vaginal pH above 4.5 (6.3 [1.4–29]) or vaginal anaerobe bacteria (18 [2.7–122]) at enrollment. A previous use of combined oral contraceptives was preventive for the acquisition of BV (0.2 [0.03–0.96]). Elimination of BV in pregnancy tended to be associated with a heavy growth of Lactobacillus (3.2 [0.8–13]) at enrollment. Conclusions: acquisition of BV during pregnancy is rare and is associated with smoking, while the presence of anaerobe bacteria and a vaginal pH > 4.5 are interpreted as steps on a gradual change towards BV. In the same way heavy growth of Lactobacillus spp in early pregnancy may be an indicator of women on the way to eliminate BV. Hindawi Publishing Corporation 2006 2006-05-25 /pmc/articles/PMC1581474/ /pubmed/17485815 http://dx.doi.org/10.1155/IDOG/2006/94646 Text en Copyright © 2006 Ida Vogel et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Vogel, Ida
Thorsen, Poul
Jeune, Bernard
Jacobsson, Bo
Ebbesen, Niels
Arpi, Magnus
Bremmelgaard, Annie
Møller, Birger R.
Acquisition and Elimination of Bacterial Vaginosis During Pregnancy: A Danish Population-Based Study
title Acquisition and Elimination of Bacterial Vaginosis During Pregnancy: A Danish Population-Based Study
title_full Acquisition and Elimination of Bacterial Vaginosis During Pregnancy: A Danish Population-Based Study
title_fullStr Acquisition and Elimination of Bacterial Vaginosis During Pregnancy: A Danish Population-Based Study
title_full_unstemmed Acquisition and Elimination of Bacterial Vaginosis During Pregnancy: A Danish Population-Based Study
title_short Acquisition and Elimination of Bacterial Vaginosis During Pregnancy: A Danish Population-Based Study
title_sort acquisition and elimination of bacterial vaginosis during pregnancy: a danish population-based study
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1581474/
https://www.ncbi.nlm.nih.gov/pubmed/17485815
http://dx.doi.org/10.1155/IDOG/2006/94646
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