A Signaling Network for Patterning of Neuronal Connectivity in the Drosophila Brain

The precise number and pattern of axonal connections generated during brain development regulates animal behavior. Therefore, understanding how developmental signals interact to regulate axonal extension and retraction to achieve precise neuronal connectivity is a fundamental goal of neurobiology. W...

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Autores principales: Srahna, Mohammed, Leyssen, Maarten, Choi, Ching Man, Fradkin, Lee G, Noordermeer, Jasprina N, Hassan, Bassem A
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592317/
https://www.ncbi.nlm.nih.gov/pubmed/17032066
http://dx.doi.org/10.1371/journal.pbio.0040348
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author Srahna, Mohammed
Leyssen, Maarten
Choi, Ching Man
Fradkin, Lee G
Noordermeer, Jasprina N
Hassan, Bassem A
author_facet Srahna, Mohammed
Leyssen, Maarten
Choi, Ching Man
Fradkin, Lee G
Noordermeer, Jasprina N
Hassan, Bassem A
author_sort Srahna, Mohammed
collection PubMed
description The precise number and pattern of axonal connections generated during brain development regulates animal behavior. Therefore, understanding how developmental signals interact to regulate axonal extension and retraction to achieve precise neuronal connectivity is a fundamental goal of neurobiology. We investigated this question in the developing adult brain of Drosophila and find that it is regulated by crosstalk between Wnt, fibroblast growth factor (FGF) receptor, and Jun N-terminal kinase (JNK) signaling, but independent of neuronal activity. The Rac1 GTPase integrates a Wnt-Frizzled-Disheveled axon-stabilizing signal and a Branchless (FGF)-Breathless (FGF receptor) axon-retracting signal to modulate JNK activity. JNK activity is necessary and sufficient for axon extension, whereas the antagonistic Wnt and FGF signals act to balance the extension and retraction required for the generation of the precise wiring pattern.
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spelling pubmed-15923172006-11-17 A Signaling Network for Patterning of Neuronal Connectivity in the Drosophila Brain Srahna, Mohammed Leyssen, Maarten Choi, Ching Man Fradkin, Lee G Noordermeer, Jasprina N Hassan, Bassem A PLoS Biol Research Article The precise number and pattern of axonal connections generated during brain development regulates animal behavior. Therefore, understanding how developmental signals interact to regulate axonal extension and retraction to achieve precise neuronal connectivity is a fundamental goal of neurobiology. We investigated this question in the developing adult brain of Drosophila and find that it is regulated by crosstalk between Wnt, fibroblast growth factor (FGF) receptor, and Jun N-terminal kinase (JNK) signaling, but independent of neuronal activity. The Rac1 GTPase integrates a Wnt-Frizzled-Disheveled axon-stabilizing signal and a Branchless (FGF)-Breathless (FGF receptor) axon-retracting signal to modulate JNK activity. JNK activity is necessary and sufficient for axon extension, whereas the antagonistic Wnt and FGF signals act to balance the extension and retraction required for the generation of the precise wiring pattern. Public Library of Science 2006-11 2006-10-10 /pmc/articles/PMC1592317/ /pubmed/17032066 http://dx.doi.org/10.1371/journal.pbio.0040348 Text en © 2006 Srahna et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Srahna, Mohammed
Leyssen, Maarten
Choi, Ching Man
Fradkin, Lee G
Noordermeer, Jasprina N
Hassan, Bassem A
A Signaling Network for Patterning of Neuronal Connectivity in the Drosophila Brain
title A Signaling Network for Patterning of Neuronal Connectivity in the Drosophila Brain
title_full A Signaling Network for Patterning of Neuronal Connectivity in the Drosophila Brain
title_fullStr A Signaling Network for Patterning of Neuronal Connectivity in the Drosophila Brain
title_full_unstemmed A Signaling Network for Patterning of Neuronal Connectivity in the Drosophila Brain
title_short A Signaling Network for Patterning of Neuronal Connectivity in the Drosophila Brain
title_sort signaling network for patterning of neuronal connectivity in the drosophila brain
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592317/
https://www.ncbi.nlm.nih.gov/pubmed/17032066
http://dx.doi.org/10.1371/journal.pbio.0040348
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