Role of glycogen synthase kinase 3 beta (GSK3β) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells

Histone deacetylase inhibitors (HDACIs) have been shown to induce apoptotic and autophagic cell death in vitro and in vivo. The molecular mechanisms that underlie these cytotoxic effects are not yet clearly understood. Recently, HDACIs were shown to induce Akt dephosphorylation by disrupting HDAC-pr...

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Detalles Bibliográficos
Autores principales: Alao, John P, Stavropoulou, Alexandra V, Lam, Eric W-F, Coombes, R Charles
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592505/
https://www.ncbi.nlm.nih.gov/pubmed/17018141
http://dx.doi.org/10.1186/1476-4598-5-40

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