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JAK Inhibitors AG-490 and WHI-P154 Decrease IFN-γ-Induced iNOS Expression and NO Production in Macrophages

In inflammation, inducible nitric oxide synthase (iNOS) produces nitric oxide (NO), which modulates inflammatory processes. We investigated the effects of Janus kinase (JAK) inhibitors, AG-490 and WHI-P154, on iNOS expression and NO production in J774 murine macrophages stimulated with interferon-γ...

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Detalles Bibliográficos
Autores principales:	Sareila, Outi, Korhonen, Riku, Kärpänniemi, Outi, Nieminen, Riina, Kankaanranta, Hannu, Moilanen, Eeva
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2006
Materias:	Research Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592588/ https://www.ncbi.nlm.nih.gov/pubmed/16883061 http://dx.doi.org/10.1155/MI/2006/16161

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