Suppression of Carrageenan- and Collagen II-Induced Inflammation in Mice by Geranium Oil

To obtain experimental evidence on the therapeutic efficacy of essential oils in aromatherapy for inflammatory diseases, we examined the effects of geranium oil on carrageenan-induced and collagen II-induced inflammation in mice, to assess acute and chronic anti-inflammatory activities of the oil. S...

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Autores principales: Maruyama, Naho, Ishibashi, Hiroko, Hu, Weimin, Morofuji, Shinichiro, Inouye, Shigeharu, Yamaguchi, Hideyo, Abe, Shigeru
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2006
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592600/
https://www.ncbi.nlm.nih.gov/pubmed/16951493
http://dx.doi.org/10.1155/MI/2006/62537
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author Maruyama, Naho
Ishibashi, Hiroko
Hu, Weimin
Morofuji, Shinichiro
Inouye, Shigeharu
Yamaguchi, Hideyo
Abe, Shigeru
author_facet Maruyama, Naho
Ishibashi, Hiroko
Hu, Weimin
Morofuji, Shinichiro
Inouye, Shigeharu
Yamaguchi, Hideyo
Abe, Shigeru
author_sort Maruyama, Naho
collection PubMed
description To obtain experimental evidence on the therapeutic efficacy of essential oils in aromatherapy for inflammatory diseases, we examined the effects of geranium oil on carrageenan-induced and collagen II-induced inflammation in mice, to assess acute and chronic anti-inflammatory activities of the oil. Single intraperitoneal injection of 5 μL of geranium oil clearly suppressed the carrageenan-induced footpaw edema and increase in tissue myeloperoxidase activity, and repeated administration of the oil suppressed collagen-induced arthritis. These results revealed that geranium oil suppressed both acute and chronic inflammatory responses in mice.
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spelling pubmed-15926002006-10-23 Suppression of Carrageenan- and Collagen II-Induced Inflammation in Mice by Geranium Oil Maruyama, Naho Ishibashi, Hiroko Hu, Weimin Morofuji, Shinichiro Inouye, Shigeharu Yamaguchi, Hideyo Abe, Shigeru Mediators Inflamm Research Communication To obtain experimental evidence on the therapeutic efficacy of essential oils in aromatherapy for inflammatory diseases, we examined the effects of geranium oil on carrageenan-induced and collagen II-induced inflammation in mice, to assess acute and chronic anti-inflammatory activities of the oil. Single intraperitoneal injection of 5 μL of geranium oil clearly suppressed the carrageenan-induced footpaw edema and increase in tissue myeloperoxidase activity, and repeated administration of the oil suppressed collagen-induced arthritis. These results revealed that geranium oil suppressed both acute and chronic inflammatory responses in mice. Hindawi Publishing Corporation 2006 2006-03-21 /pmc/articles/PMC1592600/ /pubmed/16951493 http://dx.doi.org/10.1155/MI/2006/62537 Text en Copyright © 2006 Naho Maruyama et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Communication
Maruyama, Naho
Ishibashi, Hiroko
Hu, Weimin
Morofuji, Shinichiro
Inouye, Shigeharu
Yamaguchi, Hideyo
Abe, Shigeru
Suppression of Carrageenan- and Collagen II-Induced Inflammation in Mice by Geranium Oil
title Suppression of Carrageenan- and Collagen II-Induced Inflammation in Mice by Geranium Oil
title_full Suppression of Carrageenan- and Collagen II-Induced Inflammation in Mice by Geranium Oil
title_fullStr Suppression of Carrageenan- and Collagen II-Induced Inflammation in Mice by Geranium Oil
title_full_unstemmed Suppression of Carrageenan- and Collagen II-Induced Inflammation in Mice by Geranium Oil
title_short Suppression of Carrageenan- and Collagen II-Induced Inflammation in Mice by Geranium Oil
title_sort suppression of carrageenan- and collagen ii-induced inflammation in mice by geranium oil
topic Research Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592600/
https://www.ncbi.nlm.nih.gov/pubmed/16951493
http://dx.doi.org/10.1155/MI/2006/62537
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