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Modulation of Aβ(42 )low-n oligomerization using a novel yeast reporter system
BACKGROUND: While traditional models of Alzheimer's disease focused on large fibrillar deposits of the Aβ(42 )amyloid peptide in the brain, recent work suggests that the major pathogenic effects may be attributed to SDS-stable oligomers of Aβ(42). These Aβ(42 )oligomers represent a rational tar...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2006
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1594584/ https://www.ncbi.nlm.nih.gov/pubmed/17002801 http://dx.doi.org/10.1186/1741-7007-4-32 |