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Bystander CD8 T-Cell-Mediated Demyelination is Interferon-γ-Dependent in a Coronavirus Model of Multiple Sclerosis
Mice infected with the coronavirus mouse hepatitis virus, strain JHM (JHM) develop a disease that shares many histological characteristics with multiple sclerosis. We previously demonstrated that JHM-infected mice that only have CD8 T cells specific for an epitope not in the virus develop demyelinat...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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American Society for Investigative Pathology
2004
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1602263/ https://www.ncbi.nlm.nih.gov/pubmed/14742242 |
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author | Dandekar, Ajai A. Anghelina, Daniela Perlman, Stanley |
author_facet | Dandekar, Ajai A. Anghelina, Daniela Perlman, Stanley |
author_sort | Dandekar, Ajai A. |
collection | PubMed |
description | Mice infected with the coronavirus mouse hepatitis virus, strain JHM (JHM) develop a disease that shares many histological characteristics with multiple sclerosis. We previously demonstrated that JHM-infected mice that only have CD8 T cells specific for an epitope not in the virus develop demyelination on specific activation of these cells. Herein we show that this process of bystander T-cell-mediated demyelination is interferon-γ (IFN-γ)-dependent. The absence of IFN-γ abrogated demyelination but did not change T-cell infiltration or expression levels of inflammatory cytokines or chemokines in the spinal cord. These results are consistent with models in which IFN-γ contributes to CD8 T-cell-mediated demyelination by activation of macrophages/microglia, the final effector cells in the disease process. |
format | Text |
id | pubmed-1602263 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | American Society for Investigative Pathology |
record_format | MEDLINE/PubMed |
spelling | pubmed-16022632007-03-26 Bystander CD8 T-Cell-Mediated Demyelination is Interferon-γ-Dependent in a Coronavirus Model of Multiple Sclerosis Dandekar, Ajai A. Anghelina, Daniela Perlman, Stanley Am J Pathol Short Communication Mice infected with the coronavirus mouse hepatitis virus, strain JHM (JHM) develop a disease that shares many histological characteristics with multiple sclerosis. We previously demonstrated that JHM-infected mice that only have CD8 T cells specific for an epitope not in the virus develop demyelination on specific activation of these cells. Herein we show that this process of bystander T-cell-mediated demyelination is interferon-γ (IFN-γ)-dependent. The absence of IFN-γ abrogated demyelination but did not change T-cell infiltration or expression levels of inflammatory cytokines or chemokines in the spinal cord. These results are consistent with models in which IFN-γ contributes to CD8 T-cell-mediated demyelination by activation of macrophages/microglia, the final effector cells in the disease process. American Society for Investigative Pathology 2004-02 /pmc/articles/PMC1602263/ /pubmed/14742242 Text en Copyright © American Society for Investigative Pathology |
spellingShingle | Short Communication Dandekar, Ajai A. Anghelina, Daniela Perlman, Stanley Bystander CD8 T-Cell-Mediated Demyelination is Interferon-γ-Dependent in a Coronavirus Model of Multiple Sclerosis |
title | Bystander CD8 T-Cell-Mediated Demyelination is Interferon-γ-Dependent in a Coronavirus Model of Multiple Sclerosis |
title_full | Bystander CD8 T-Cell-Mediated Demyelination is Interferon-γ-Dependent in a Coronavirus Model of Multiple Sclerosis |
title_fullStr | Bystander CD8 T-Cell-Mediated Demyelination is Interferon-γ-Dependent in a Coronavirus Model of Multiple Sclerosis |
title_full_unstemmed | Bystander CD8 T-Cell-Mediated Demyelination is Interferon-γ-Dependent in a Coronavirus Model of Multiple Sclerosis |
title_short | Bystander CD8 T-Cell-Mediated Demyelination is Interferon-γ-Dependent in a Coronavirus Model of Multiple Sclerosis |
title_sort | bystander cd8 t-cell-mediated demyelination is interferon-γ-dependent in a coronavirus model of multiple sclerosis |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1602263/ https://www.ncbi.nlm.nih.gov/pubmed/14742242 |
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