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Loss of Angiotensin-Converting Enzyme-2 Leads to the Late Development of Angiotensin II-Dependent Glomerulosclerosis

Angiotensin-converting enzyme-2 (ACE2), a membrane-bound carboxymonopeptidase highly expressed in the kidney, functions as a negative regulator of the renin-angiotensin system. Here we report early accumulation of fibrillar collagen in the glomerular mesangium of male ACE2 mutant (ACE2(−/y)) mice fo...

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Detalles Bibliográficos
Autores principales:	Oudit, Gavin Y., Herzenberg, Andrew M., Kassiri, Zamaneh, Wong, Denise, Reich, Heather, Khokha, Rama, Crackower, Michael A., Backx, Peter H., Penninger, Josef M., Scholey, James W.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Investigative Pathology 2006
Materias:	Regular Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1606622/ https://www.ncbi.nlm.nih.gov/pubmed/16723697 http://dx.doi.org/10.2353/ajpath.2006.051091

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