Flip-Flop HSV-BAC: bacterial artificial chromosome based system for rapid generation of recombinant herpes simplex virus vectors using two independent site-specific recombinases

BACKGROUND: Oncolytic herpes simplex virus (HSV) vectors that specifically replicate in and kill tumor cells sparing normal cells are a promising cancer therapy. Traditionally, recombinant HSV vectors have been generated through homologous recombination between the HSV genome and a recombination pla...

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Detalles Bibliográficos
Autores principales: Kuroda, Toshihiko, Martuza, Robert L, Todo, Tomoki, Rabkin, Samuel D
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1609115/
https://www.ncbi.nlm.nih.gov/pubmed/16995942
http://dx.doi.org/10.1186/1472-6750-6-40

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