Cargando…

Anatomical Alterations of the Visual Motion Processing Network in Migraine with and without Aura

BACKGROUND: Patients suffering from migraine with aura (MWA) and migraine without aura (MWoA) show abnormalities in visual motion perception during and between attacks. Whether this represents the consequences of structural changes in motion-processing networks in migraineurs is unknown. Moreover, t...

Descripción completa

Detalles Bibliográficos
Autores principales: Granziera, Cristina, DaSilva, Alexandre F. M, Snyder, Josh, Tuch, David S, Hadjikhani, Nouchine
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1609120/
https://www.ncbi.nlm.nih.gov/pubmed/17048979
http://dx.doi.org/10.1371/journal.pmed.0030402
_version_ 1782130466689646592
author Granziera, Cristina
DaSilva, Alexandre F. M
Snyder, Josh
Tuch, David S
Hadjikhani, Nouchine
author_facet Granziera, Cristina
DaSilva, Alexandre F. M
Snyder, Josh
Tuch, David S
Hadjikhani, Nouchine
author_sort Granziera, Cristina
collection PubMed
description BACKGROUND: Patients suffering from migraine with aura (MWA) and migraine without aura (MWoA) show abnormalities in visual motion perception during and between attacks. Whether this represents the consequences of structural changes in motion-processing networks in migraineurs is unknown. Moreover, the diagnosis of migraine relies on patient's history, and finding differences in the brain of migraineurs might help to contribute to basic research aimed at better understanding the pathophysiology of migraine. METHODS AND FINDINGS: To investigate a common potential anatomical basis for these disturbances, we used high-resolution cortical thickness measurement and diffusion tensor imaging (DTI) to examine the motion-processing network in 24 migraine patients (12 with MWA and 12 MWoA) and 15 age-matched healthy controls (HCs). We found increased cortical thickness of motion-processing visual areas MT+ and V3A in migraineurs compared to HCs. Cortical thickness increases were accompanied by abnormalities of the subjacent white matter. In addition, DTI revealed that migraineurs have alterations in superior colliculus and the lateral geniculate nucleus, which are also involved in visual processing. CONCLUSIONS: A structural abnormality in the network of motion-processing areas could account for, or be the result of, the cortical hyperexcitability observed in migraineurs. The finding in patients with both MWA and MWoA of thickness abnormalities in area V3A, previously described as a source in spreading changes involved in visual aura, raises the question as to whether a “silent” cortical spreading depression develops as well in MWoA. In addition, these experimental data may provide clinicians and researchers with a noninvasively acquirable migraine biomarker.
format Text
id pubmed-1609120
institution National Center for Biotechnology Information
language English
publishDate 2006
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-16091202006-10-17 Anatomical Alterations of the Visual Motion Processing Network in Migraine with and without Aura Granziera, Cristina DaSilva, Alexandre F. M Snyder, Josh Tuch, David S Hadjikhani, Nouchine PLoS Med Research Article BACKGROUND: Patients suffering from migraine with aura (MWA) and migraine without aura (MWoA) show abnormalities in visual motion perception during and between attacks. Whether this represents the consequences of structural changes in motion-processing networks in migraineurs is unknown. Moreover, the diagnosis of migraine relies on patient's history, and finding differences in the brain of migraineurs might help to contribute to basic research aimed at better understanding the pathophysiology of migraine. METHODS AND FINDINGS: To investigate a common potential anatomical basis for these disturbances, we used high-resolution cortical thickness measurement and diffusion tensor imaging (DTI) to examine the motion-processing network in 24 migraine patients (12 with MWA and 12 MWoA) and 15 age-matched healthy controls (HCs). We found increased cortical thickness of motion-processing visual areas MT+ and V3A in migraineurs compared to HCs. Cortical thickness increases were accompanied by abnormalities of the subjacent white matter. In addition, DTI revealed that migraineurs have alterations in superior colliculus and the lateral geniculate nucleus, which are also involved in visual processing. CONCLUSIONS: A structural abnormality in the network of motion-processing areas could account for, or be the result of, the cortical hyperexcitability observed in migraineurs. The finding in patients with both MWA and MWoA of thickness abnormalities in area V3A, previously described as a source in spreading changes involved in visual aura, raises the question as to whether a “silent” cortical spreading depression develops as well in MWoA. In addition, these experimental data may provide clinicians and researchers with a noninvasively acquirable migraine biomarker. Public Library of Science 2006-10 2006-10-17 /pmc/articles/PMC1609120/ /pubmed/17048979 http://dx.doi.org/10.1371/journal.pmed.0030402 Text en © 2006 Granziera et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Granziera, Cristina
DaSilva, Alexandre F. M
Snyder, Josh
Tuch, David S
Hadjikhani, Nouchine
Anatomical Alterations of the Visual Motion Processing Network in Migraine with and without Aura
title Anatomical Alterations of the Visual Motion Processing Network in Migraine with and without Aura
title_full Anatomical Alterations of the Visual Motion Processing Network in Migraine with and without Aura
title_fullStr Anatomical Alterations of the Visual Motion Processing Network in Migraine with and without Aura
title_full_unstemmed Anatomical Alterations of the Visual Motion Processing Network in Migraine with and without Aura
title_short Anatomical Alterations of the Visual Motion Processing Network in Migraine with and without Aura
title_sort anatomical alterations of the visual motion processing network in migraine with and without aura
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1609120/
https://www.ncbi.nlm.nih.gov/pubmed/17048979
http://dx.doi.org/10.1371/journal.pmed.0030402
work_keys_str_mv AT granzieracristina anatomicalalterationsofthevisualmotionprocessingnetworkinmigrainewithandwithoutaura
AT dasilvaalexandrefm anatomicalalterationsofthevisualmotionprocessingnetworkinmigrainewithandwithoutaura
AT snyderjosh anatomicalalterationsofthevisualmotionprocessingnetworkinmigrainewithandwithoutaura
AT tuchdavids anatomicalalterationsofthevisualmotionprocessingnetworkinmigrainewithandwithoutaura
AT hadjikhaninouchine anatomicalalterationsofthevisualmotionprocessingnetworkinmigrainewithandwithoutaura