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RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts

BACKGROUND: Incorrect segregation of whole chromosomes or parts of chromosome leads to aneuploidy commonly observed in cancer. The correct centrosome duplication, assuring assembly of a bipolar mitotic spindle, is essential for chromosome segregation fidelity and preventing aneuploidy. Alteration of...

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Detalles Bibliográficos
Autores principales:	Iovino, Flora, Lentini, Laura, Amato, Angela, Di Leonardo, Aldo
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2006
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1613254/ https://www.ncbi.nlm.nih.gov/pubmed/16987420 http://dx.doi.org/10.1186/1476-4598-5-38

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