Sit down, relax and unwind: structural insights into RecQ helicase mechanisms

Helicases are specialized molecular motors that separate duplex nucleic acids into single strands. The RecQ family of helicases functions at the interface of DNA replication, recombination and repair in bacterial and eukaryotic cells. They are key, multifunctional enzymes that have been linked to th...

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Detalles Bibliográficos
Autores principales: Killoran, Michael P., Keck, James L.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Survey and Summary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1616949/
https://www.ncbi.nlm.nih.gov/pubmed/16935877
http://dx.doi.org/10.1093/nar/gkl538
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author Killoran, Michael P.
Keck, James L.
author_facet Killoran, Michael P.
Keck, James L.
author_sort Killoran, Michael P.
collection PubMed
description Helicases are specialized molecular motors that separate duplex nucleic acids into single strands. The RecQ family of helicases functions at the interface of DNA replication, recombination and repair in bacterial and eukaryotic cells. They are key, multifunctional enzymes that have been linked to three human diseases: Bloom's, Werner's and Rothmund–Thomson's syndromes. This review summarizes recent studies that relate the structures of RecQ proteins to their biochemical activities.
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spelling pubmed-16169492006-10-27 Sit down, relax and unwind: structural insights into RecQ helicase mechanisms Killoran, Michael P. Keck, James L. Nucleic Acids Res Survey and Summary Helicases are specialized molecular motors that separate duplex nucleic acids into single strands. The RecQ family of helicases functions at the interface of DNA replication, recombination and repair in bacterial and eukaryotic cells. They are key, multifunctional enzymes that have been linked to three human diseases: Bloom's, Werner's and Rothmund–Thomson's syndromes. This review summarizes recent studies that relate the structures of RecQ proteins to their biochemical activities. Oxford University Press 2006-09 2006-08-25 /pmc/articles/PMC1616949/ /pubmed/16935877 http://dx.doi.org/10.1093/nar/gkl538 Text en © 2006 The Author(s)
spellingShingle Survey and Summary
Killoran, Michael P.
Keck, James L.
Sit down, relax and unwind: structural insights into RecQ helicase mechanisms
title Sit down, relax and unwind: structural insights into RecQ helicase mechanisms
title_full Sit down, relax and unwind: structural insights into RecQ helicase mechanisms
title_fullStr Sit down, relax and unwind: structural insights into RecQ helicase mechanisms
title_full_unstemmed Sit down, relax and unwind: structural insights into RecQ helicase mechanisms
title_short Sit down, relax and unwind: structural insights into RecQ helicase mechanisms
title_sort sit down, relax and unwind: structural insights into recq helicase mechanisms
topic Survey and Summary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1616949/
https://www.ncbi.nlm.nih.gov/pubmed/16935877
http://dx.doi.org/10.1093/nar/gkl538
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