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Structural basis for topoisomerase VI inhibition by the anti-Hsp90 drug radicicol
Members of the GHL ATPase superfamily, including type II topoisomerases, Hsp90-class chaperones, and MutL, all share a common GHKL-type ATP-binding fold and act as nucleotide-controlled ‘molecular clamps’. These enzymes' ATP-binding sites have proven to be rich drug targets, and certain inhibit...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2006
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1616964/ https://www.ncbi.nlm.nih.gov/pubmed/16920739 http://dx.doi.org/10.1093/nar/gkl567 |