Abnormal expansion of naïve B lymphocytes after unrelated cord blood transplantation – a case report

A 33-year-old woman underwent unrelated cord blood transplantation (U-CBT) for myelodysplastic syndrome (MDS)-related secondary AML. She showed impressive increases in the number of CD19(+) B cells in bone marrow and CD19(+)27(−)IgD(+) B cells in peripheral blood from about 1 month to 3 months after...

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Detalles Bibliográficos
Autores principales: SHONO, Y, TOUBAI, T, OTA, S, IBATA, M, MASHIKO, S, HIRATE, D, MIURA, Y, UMEHARA, S, TOYOSHIMA, N, TANAKA, J, ASAKA, M, IMAMURA, M
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2006
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618819/
https://www.ncbi.nlm.nih.gov/pubmed/16999729
http://dx.doi.org/10.1111/j.1365-2257.2006.00809.x
Descripción
Sumario:A 33-year-old woman underwent unrelated cord blood transplantation (U-CBT) for myelodysplastic syndrome (MDS)-related secondary AML. She showed impressive increases in the number of CD19(+) B cells in bone marrow and CD19(+)27(−)IgD(+) B cells in peripheral blood from about 1 month to 3 months after U-CBT. The serum level of IL-6 temporarily increased after transplantation, and this increase seemed to be correlated with the expansion of CD19(+) B cells. Although, compared with BMT, little is known about the kinetics of hematological and immunological reconstitution in U-CBT, there was initial B-cell recovery after CBT as some described. This B cell recovery may be associated with a high number of B-cell precursors present in cord blood (CB). The phenomenon of naïve B lymphocyte expansion that we found might be associated with a high number of B-cell precursors present in CB.

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