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Influence of Interleukin IL-2 and IL-12 + IL-18 on Surface Expression of Immunoglobulin-Like Receptors KIR2DL1, KIR2DL2, and KIR3DL2 in Natural Killer Cells
Natural killer (NK) cells express killer cell inhibitory receptors (KIRs) that recognize polymorphic class I MHC molecules. In the present study, we analyze the modulatory effect of IL-2 alone or a combination of IL-12 with IL-18 on surface expression of killer cell immunoglobulin-like receptors KIR...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618942/ https://www.ncbi.nlm.nih.gov/pubmed/17047292 http://dx.doi.org/10.1155/MI/2006/46957 |
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author | Chrul, Slawomir Polakowska, Ewa Szadkowska, Agnieszka Bodalski, Jerzy |
author_facet | Chrul, Slawomir Polakowska, Ewa Szadkowska, Agnieszka Bodalski, Jerzy |
author_sort | Chrul, Slawomir |
collection | PubMed |
description | Natural killer (NK) cells express killer cell inhibitory receptors (KIRs) that recognize polymorphic class I MHC molecules. In the present study, we analyze the modulatory effect of IL-2 alone or a combination of IL-12 with IL-18 on surface expression of killer cell immunoglobulin-like receptors KIR2DL1, KIR2DL2, and KIR3DL2 in NK cells. Thus, it was found that IL-2 causes a significant increase in the proportion of cells with given studied receptors. Stimulation by a mixture of IL-12 and IL-18 caused significant increase in the fraction of cells with the KIR2DL1 and KIR2DL2, however no significant change in the percentage of cells with KIR3DL2 receptor on their surface was observed. The results of the study show the presence of KIRs on both resting and activated NK cells, this may suggest that KIRs have also an important role in the regulatory processes after activation of this subpopulation of cells. |
format | Text |
id | pubmed-1618942 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-16189422006-11-15 Influence of Interleukin IL-2 and IL-12 + IL-18 on Surface Expression of Immunoglobulin-Like Receptors KIR2DL1, KIR2DL2, and KIR3DL2 in Natural Killer Cells Chrul, Slawomir Polakowska, Ewa Szadkowska, Agnieszka Bodalski, Jerzy Mediators Inflamm Research Communication Natural killer (NK) cells express killer cell inhibitory receptors (KIRs) that recognize polymorphic class I MHC molecules. In the present study, we analyze the modulatory effect of IL-2 alone or a combination of IL-12 with IL-18 on surface expression of killer cell immunoglobulin-like receptors KIR2DL1, KIR2DL2, and KIR3DL2 in NK cells. Thus, it was found that IL-2 causes a significant increase in the proportion of cells with given studied receptors. Stimulation by a mixture of IL-12 and IL-18 caused significant increase in the fraction of cells with the KIR2DL1 and KIR2DL2, however no significant change in the percentage of cells with KIR3DL2 receptor on their surface was observed. The results of the study show the presence of KIRs on both resting and activated NK cells, this may suggest that KIRs have also an important role in the regulatory processes after activation of this subpopulation of cells. Hindawi Publishing Corporation 2006 2006-06-12 /pmc/articles/PMC1618942/ /pubmed/17047292 http://dx.doi.org/10.1155/MI/2006/46957 Text en Copyright © 2006 Slawomir Chrul et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Communication Chrul, Slawomir Polakowska, Ewa Szadkowska, Agnieszka Bodalski, Jerzy Influence of Interleukin IL-2 and IL-12 + IL-18 on Surface Expression of Immunoglobulin-Like Receptors KIR2DL1, KIR2DL2, and KIR3DL2 in Natural Killer Cells |
title | Influence of Interleukin IL-2 and IL-12 +
IL-18 on Surface Expression of Immunoglobulin-Like
Receptors KIR2DL1, KIR2DL2, and KIR3DL2 in Natural Killer Cells |
title_full | Influence of Interleukin IL-2 and IL-12 +
IL-18 on Surface Expression of Immunoglobulin-Like
Receptors KIR2DL1, KIR2DL2, and KIR3DL2 in Natural Killer Cells |
title_fullStr | Influence of Interleukin IL-2 and IL-12 +
IL-18 on Surface Expression of Immunoglobulin-Like
Receptors KIR2DL1, KIR2DL2, and KIR3DL2 in Natural Killer Cells |
title_full_unstemmed | Influence of Interleukin IL-2 and IL-12 +
IL-18 on Surface Expression of Immunoglobulin-Like
Receptors KIR2DL1, KIR2DL2, and KIR3DL2 in Natural Killer Cells |
title_short | Influence of Interleukin IL-2 and IL-12 +
IL-18 on Surface Expression of Immunoglobulin-Like
Receptors KIR2DL1, KIR2DL2, and KIR3DL2 in Natural Killer Cells |
title_sort | influence of interleukin il-2 and il-12 +
il-18 on surface expression of immunoglobulin-like
receptors kir2dl1, kir2dl2, and kir3dl2 in natural killer cells |
topic | Research Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618942/ https://www.ncbi.nlm.nih.gov/pubmed/17047292 http://dx.doi.org/10.1155/MI/2006/46957 |
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