Is the Association Between TNF-α-308 A Allele and DMT1 Independent of HLA-DRB1, DQB1 Alleles?

The aim of the study was to assess chosen factors of genetic susceptibility to DMT1: DRB1, DQB1, and TNF-α polymorphisms-308 (G/A) in children with DMT1 and their up-to-now healthy siblings. Then we tested whether the association between TNF-α genes and DMT1 is independent of HLA. 87 diabetic childr...

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Autores principales: Deja, Grażyna, Jarosz-Chobot, Przemysława, Polańska, Joanna, Siekiera, Urszula, Małecka-Tendera, Ewa
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2006
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618952/
https://www.ncbi.nlm.nih.gov/pubmed/17047287
http://dx.doi.org/10.1155/MI/2006/19724
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author Deja, Grażyna
Jarosz-Chobot, Przemysława
Polańska, Joanna
Siekiera, Urszula
Małecka-Tendera, Ewa
author_facet Deja, Grażyna
Jarosz-Chobot, Przemysława
Polańska, Joanna
Siekiera, Urszula
Małecka-Tendera, Ewa
author_sort Deja, Grażyna
collection PubMed
description The aim of the study was to assess chosen factors of genetic susceptibility to DMT1: DRB1, DQB1, and TNF-α polymorphisms-308 (G/A) in children with DMT1 and their up-to-now healthy siblings. Then we tested whether the association between TNF-α genes and DMT1 is independent of HLA. 87 diabetic children, their 78 siblings, and 85 persons from healthy control group were followed up. The highest risk of DMT1 was connected with alleles: DRB1*0401 (OR = 3.39; CI: 1.55–7.41), DRB1*0301 (OR = 2.72; CI: 1.48–5.01), DQB1*0201 (OR = 4.04; CI: 2.17–7.52), DQB1*0302 (OR = 5.08; CI: 2.54–10.14), and TNF-α-308 A allele (OR = 2.59; CI: 1.23–5.44). Moreover linkage disequilibrium for TNF-α-308 A allele with DRB1*0301 and DQB1*0201 was observed in both diabetic children and their siblings. Diabetic children and their siblings present similar genetic risk factors for DMT1. The association between TNF-α-308 A allele and DMT1 is dependent of HLA-DRB1 and DQB1 alleles.
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spelling pubmed-16189522006-11-15 Is the Association Between TNF-α-308 A Allele and DMT1 Independent of HLA-DRB1, DQB1 Alleles? Deja, Grażyna Jarosz-Chobot, Przemysława Polańska, Joanna Siekiera, Urszula Małecka-Tendera, Ewa Mediators Inflamm Research Communication The aim of the study was to assess chosen factors of genetic susceptibility to DMT1: DRB1, DQB1, and TNF-α polymorphisms-308 (G/A) in children with DMT1 and their up-to-now healthy siblings. Then we tested whether the association between TNF-α genes and DMT1 is independent of HLA. 87 diabetic children, their 78 siblings, and 85 persons from healthy control group were followed up. The highest risk of DMT1 was connected with alleles: DRB1*0401 (OR = 3.39; CI: 1.55–7.41), DRB1*0301 (OR = 2.72; CI: 1.48–5.01), DQB1*0201 (OR = 4.04; CI: 2.17–7.52), DQB1*0302 (OR = 5.08; CI: 2.54–10.14), and TNF-α-308 A allele (OR = 2.59; CI: 1.23–5.44). Moreover linkage disequilibrium for TNF-α-308 A allele with DRB1*0301 and DQB1*0201 was observed in both diabetic children and their siblings. Diabetic children and their siblings present similar genetic risk factors for DMT1. The association between TNF-α-308 A allele and DMT1 is dependent of HLA-DRB1 and DQB1 alleles. Hindawi Publishing Corporation 2006 2006-07-09 /pmc/articles/PMC1618952/ /pubmed/17047287 http://dx.doi.org/10.1155/MI/2006/19724 Text en Copyright © 2006 Grażyna Deja et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Communication
Deja, Grażyna
Jarosz-Chobot, Przemysława
Polańska, Joanna
Siekiera, Urszula
Małecka-Tendera, Ewa
Is the Association Between TNF-α-308 A Allele and DMT1 Independent of HLA-DRB1, DQB1 Alleles?
title Is the Association Between TNF-α-308 A Allele and DMT1 Independent of HLA-DRB1, DQB1 Alleles?
title_full Is the Association Between TNF-α-308 A Allele and DMT1 Independent of HLA-DRB1, DQB1 Alleles?
title_fullStr Is the Association Between TNF-α-308 A Allele and DMT1 Independent of HLA-DRB1, DQB1 Alleles?
title_full_unstemmed Is the Association Between TNF-α-308 A Allele and DMT1 Independent of HLA-DRB1, DQB1 Alleles?
title_short Is the Association Between TNF-α-308 A Allele and DMT1 Independent of HLA-DRB1, DQB1 Alleles?
title_sort is the association between tnf-α-308 a allele and dmt1 independent of hla-drb1, dqb1 alleles?
topic Research Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618952/
https://www.ncbi.nlm.nih.gov/pubmed/17047287
http://dx.doi.org/10.1155/MI/2006/19724
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