Inactivation of tumor suppressor Dlg1 augments transformation of a T-cell line induced by human T-cell leukemia virus type 1 Tax protein

BACKGROUND: The interaction of human T-cell leukemia virus type 1 (HTLV-1) Tax1 protein with the tumor suppressor Dlg1 is correlated with cellular transformation. RESULTS: Here, we show that Dlg1 knockdown by RNA interference increases the ability of Tax1 to transform a mouse T-cell line (CTLL-2), a...

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Detalles Bibliográficos
Autores principales: Ishioka, Kojiro, Higuchi, Masaya, Takahashi, Masahiko, Yoshida, Sakiko, Oie, Masayasu, Tanaka, Yuetsu, Takahashi, Sugata, Xie, Li, Green, Patrick L, Fujii, Masahiro
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1622753/
https://www.ncbi.nlm.nih.gov/pubmed/17042961
http://dx.doi.org/10.1186/1742-4690-3-71

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