Cargando…
Age- and Concentration-Dependent Elimination Half-Life of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Seveso Children
OBJECTIVE: Pharmacokinetic and statistical analyses are reported to elucidate key variables affecting 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) elimination in children and adolescents. DESIGN: We used blood concentrations to calculate TCDD elimination half-life. Variables examined by statistical an...
Autores principales: | , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
National Institute of Environmental Health Sciences
2006
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1626409/ https://www.ncbi.nlm.nih.gov/pubmed/17035149 http://dx.doi.org/10.1289/ehp.8884 |
_version_ | 1782130591243698176 |
---|---|
author | Kerger, Brent D. Leung, Hon-Wing Scott, Paul Paustenbach, Dennis J. Needham, Larry L. Patterson, Donald G. Gerthoux, Pier M. Mocarelli, Paolo |
author_facet | Kerger, Brent D. Leung, Hon-Wing Scott, Paul Paustenbach, Dennis J. Needham, Larry L. Patterson, Donald G. Gerthoux, Pier M. Mocarelli, Paolo |
author_sort | Kerger, Brent D. |
collection | PubMed |
description | OBJECTIVE: Pharmacokinetic and statistical analyses are reported to elucidate key variables affecting 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) elimination in children and adolescents. DESIGN: We used blood concentrations to calculate TCDD elimination half-life. Variables examined by statistical analysis include age, latency from exposure, sex, TCDD concentration and quantity in the body, severity of chloracne response, body mass index, and body fat mass. PARTICIPANTS: Blood was collected from 1976 to 1993 from residents of Seveso, Italy, who were < 18 years of age at the time of a nearby trichlorophenol reactor explosion in July 1976. RESULTS: TCDD half-life in persons < 18 years of age averaged 1.6 years while those ≥18 years of age averaged 3.2 years. Half-life is strongly associated with age, showing a cohort average increase of 0.12 year half-life per year of age or time since exposure. A significant concentration-dependency is also identified, showing shorter half-lives for TCDD concentrations > 400 ppt for children < 12 years of age and 700 ppt when including adults. Moderate correlations are also observed between half-life and body mass index, body fat mass, TCDD mass, and chloracne response. CONCLUSIONS: Children and adolescents have shorter TCDD half-lives and a slower rate of increase in half-life than adults, and this effect is augmented at higher body burdens. RELEVANCE: Modeling of TCDD blood concentrations or body burden in humans should take into account the markedly shorter elimination half-life observed in children and adolescents and concentration-dependent effects observed in persons > 400–700 ppt. |
format | Text |
id | pubmed-1626409 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-16264092006-11-08 Age- and Concentration-Dependent Elimination Half-Life of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Seveso Children Kerger, Brent D. Leung, Hon-Wing Scott, Paul Paustenbach, Dennis J. Needham, Larry L. Patterson, Donald G. Gerthoux, Pier M. Mocarelli, Paolo Environ Health Perspect Research OBJECTIVE: Pharmacokinetic and statistical analyses are reported to elucidate key variables affecting 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) elimination in children and adolescents. DESIGN: We used blood concentrations to calculate TCDD elimination half-life. Variables examined by statistical analysis include age, latency from exposure, sex, TCDD concentration and quantity in the body, severity of chloracne response, body mass index, and body fat mass. PARTICIPANTS: Blood was collected from 1976 to 1993 from residents of Seveso, Italy, who were < 18 years of age at the time of a nearby trichlorophenol reactor explosion in July 1976. RESULTS: TCDD half-life in persons < 18 years of age averaged 1.6 years while those ≥18 years of age averaged 3.2 years. Half-life is strongly associated with age, showing a cohort average increase of 0.12 year half-life per year of age or time since exposure. A significant concentration-dependency is also identified, showing shorter half-lives for TCDD concentrations > 400 ppt for children < 12 years of age and 700 ppt when including adults. Moderate correlations are also observed between half-life and body mass index, body fat mass, TCDD mass, and chloracne response. CONCLUSIONS: Children and adolescents have shorter TCDD half-lives and a slower rate of increase in half-life than adults, and this effect is augmented at higher body burdens. RELEVANCE: Modeling of TCDD blood concentrations or body burden in humans should take into account the markedly shorter elimination half-life observed in children and adolescents and concentration-dependent effects observed in persons > 400–700 ppt. National Institute of Environmental Health Sciences 2006-10 2006-07-06 /pmc/articles/PMC1626409/ /pubmed/17035149 http://dx.doi.org/10.1289/ehp.8884 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research Kerger, Brent D. Leung, Hon-Wing Scott, Paul Paustenbach, Dennis J. Needham, Larry L. Patterson, Donald G. Gerthoux, Pier M. Mocarelli, Paolo Age- and Concentration-Dependent Elimination Half-Life of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Seveso Children |
title | Age- and Concentration-Dependent Elimination Half-Life of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Seveso Children |
title_full | Age- and Concentration-Dependent Elimination Half-Life of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Seveso Children |
title_fullStr | Age- and Concentration-Dependent Elimination Half-Life of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Seveso Children |
title_full_unstemmed | Age- and Concentration-Dependent Elimination Half-Life of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Seveso Children |
title_short | Age- and Concentration-Dependent Elimination Half-Life of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Seveso Children |
title_sort | age- and concentration-dependent elimination half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in seveso children |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1626409/ https://www.ncbi.nlm.nih.gov/pubmed/17035149 http://dx.doi.org/10.1289/ehp.8884 |
work_keys_str_mv | AT kergerbrentd ageandconcentrationdependenteliminationhalflifeof2378tetrachlorodibenzopdioxininsevesochildren AT leunghonwing ageandconcentrationdependenteliminationhalflifeof2378tetrachlorodibenzopdioxininsevesochildren AT scottpaul ageandconcentrationdependenteliminationhalflifeof2378tetrachlorodibenzopdioxininsevesochildren AT paustenbachdennisj ageandconcentrationdependenteliminationhalflifeof2378tetrachlorodibenzopdioxininsevesochildren AT needhamlarryl ageandconcentrationdependenteliminationhalflifeof2378tetrachlorodibenzopdioxininsevesochildren AT pattersondonaldg ageandconcentrationdependenteliminationhalflifeof2378tetrachlorodibenzopdioxininsevesochildren AT gerthouxpierm ageandconcentrationdependenteliminationhalflifeof2378tetrachlorodibenzopdioxininsevesochildren AT mocarellipaolo ageandconcentrationdependenteliminationhalflifeof2378tetrachlorodibenzopdioxininsevesochildren |