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Host-virus interaction: a new role for microRNAs
MicroRNAs (miRNAs) are a new class of 18–23 nucleotide long non-coding RNAs that play critical roles in a wide spectrum of biological processes. Recent reports also throw light into the role of microRNAs as critical effectors in the intricate host-pathogen interaction networks. Evidence suggests tha...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1626483/ https://www.ncbi.nlm.nih.gov/pubmed/17032463 http://dx.doi.org/10.1186/1742-4690-3-68 |
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author | Scaria, Vinod Hariharan, Manoj Maiti, Souvik Pillai, Beena Brahmachari, Samir K |
author_facet | Scaria, Vinod Hariharan, Manoj Maiti, Souvik Pillai, Beena Brahmachari, Samir K |
author_sort | Scaria, Vinod |
collection | PubMed |
description | MicroRNAs (miRNAs) are a new class of 18–23 nucleotide long non-coding RNAs that play critical roles in a wide spectrum of biological processes. Recent reports also throw light into the role of microRNAs as critical effectors in the intricate host-pathogen interaction networks. Evidence suggests that both virus and hosts encode microRNAs. The exclusive dependence of viruses on the host cellular machinery for their propagation and survival also make them highly susceptible to the vagaries of the cellular environment like small RNA mediated interference. It also gives the virus an opportunity to fight and/or modulate the host to suite its needs. Thus the range of interactions possible through miRNA-mRNA cross-talk at the host-pathogen interface is large. These interactions can be further fine-tuned in the host by changes in gene expression, mutations and polymorphisms. In the pathogen, the high rate of mutations adds to the complexity of the interaction network. Though evidence regarding microRNA mediated cross-talk in viral infections is just emerging, it offers an immense opportunity not only to understand the intricacies of host-pathogen interactions, and possible explanations to viral tropism, latency and oncogenesis, but also to develop novel biomarkers and therapeutics. |
format | Text |
id | pubmed-1626483 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-16264832006-10-28 Host-virus interaction: a new role for microRNAs Scaria, Vinod Hariharan, Manoj Maiti, Souvik Pillai, Beena Brahmachari, Samir K Retrovirology Review MicroRNAs (miRNAs) are a new class of 18–23 nucleotide long non-coding RNAs that play critical roles in a wide spectrum of biological processes. Recent reports also throw light into the role of microRNAs as critical effectors in the intricate host-pathogen interaction networks. Evidence suggests that both virus and hosts encode microRNAs. The exclusive dependence of viruses on the host cellular machinery for their propagation and survival also make them highly susceptible to the vagaries of the cellular environment like small RNA mediated interference. It also gives the virus an opportunity to fight and/or modulate the host to suite its needs. Thus the range of interactions possible through miRNA-mRNA cross-talk at the host-pathogen interface is large. These interactions can be further fine-tuned in the host by changes in gene expression, mutations and polymorphisms. In the pathogen, the high rate of mutations adds to the complexity of the interaction network. Though evidence regarding microRNA mediated cross-talk in viral infections is just emerging, it offers an immense opportunity not only to understand the intricacies of host-pathogen interactions, and possible explanations to viral tropism, latency and oncogenesis, but also to develop novel biomarkers and therapeutics. BioMed Central 2006-10-11 /pmc/articles/PMC1626483/ /pubmed/17032463 http://dx.doi.org/10.1186/1742-4690-3-68 Text en Copyright © 2006 Scaria et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Scaria, Vinod Hariharan, Manoj Maiti, Souvik Pillai, Beena Brahmachari, Samir K Host-virus interaction: a new role for microRNAs |
title | Host-virus interaction: a new role for microRNAs |
title_full | Host-virus interaction: a new role for microRNAs |
title_fullStr | Host-virus interaction: a new role for microRNAs |
title_full_unstemmed | Host-virus interaction: a new role for microRNAs |
title_short | Host-virus interaction: a new role for microRNAs |
title_sort | host-virus interaction: a new role for micrornas |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1626483/ https://www.ncbi.nlm.nih.gov/pubmed/17032463 http://dx.doi.org/10.1186/1742-4690-3-68 |
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