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Fluorescence in situ hybridization (FISH) analysis of primary ocular adnexal MALT lymphoma

BACKGROUND: It remains unknown whether primary ocular adnexal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a homogeneous entity, as there are few reports of the results of cytogenetic or molecular analyses of these tumors. METHODS: We performed int...

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Autores principales: Tanimoto, Kazuki, Sekiguchi, Naohiro, Yokota, Yukiko, Kaneko, Akihiro, Watanabe, Takashi, Maeshima, Akiko Miyagi, Matsuno, Yoshihiro, Harada, Mine, Tobinai, Kensei, Kobayashi, Yukio
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1630703/
https://www.ncbi.nlm.nih.gov/pubmed/17052360
http://dx.doi.org/10.1186/1471-2407-6-249
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author Tanimoto, Kazuki
Sekiguchi, Naohiro
Yokota, Yukiko
Kaneko, Akihiro
Watanabe, Takashi
Maeshima, Akiko Miyagi
Matsuno, Yoshihiro
Harada, Mine
Tobinai, Kensei
Kobayashi, Yukio
author_facet Tanimoto, Kazuki
Sekiguchi, Naohiro
Yokota, Yukiko
Kaneko, Akihiro
Watanabe, Takashi
Maeshima, Akiko Miyagi
Matsuno, Yoshihiro
Harada, Mine
Tobinai, Kensei
Kobayashi, Yukio
author_sort Tanimoto, Kazuki
collection PubMed
description BACKGROUND: It remains unknown whether primary ocular adnexal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a homogeneous entity, as there are few reports of the results of cytogenetic or molecular analyses of these tumors. METHODS: We performed interphase fluorescence in situ hybridization (FISH) analysis to detect translocations and aneuploidy in 34 cases of primary ocular adnexal MALT lymphoma, and reviewed the histopathological findings. Correlations between the results of FISH analysis, the histopathological features and the clinical data were also analyzed. RESULTS: Among the 34 cases, FISH analysis revealed t(14;18)(q32;q21) in one case, trisomy 3 in 21 cases (62%), and trisomy 18 in 16 cases (47%). The cases with trisomy 18 had significantly more prominent lymphoepithelial lesions (LELs) and less nodularity in the tumors. In regard to the clinical correlations, tumors with trisomy 18 were observed predominantly in females and younger patients; also, in the majority of the cases, the tumor was of conjunctival origin. All the cases with recurrence showed trisomy 18 in the tumor. CONCLUSION: Primary ocular adnexal MALT lymphoma is a significantly heterogeneous entity. Cases with trisomy 18 may have unique clinicopathological features.
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spelling pubmed-16307032006-11-02 Fluorescence in situ hybridization (FISH) analysis of primary ocular adnexal MALT lymphoma Tanimoto, Kazuki Sekiguchi, Naohiro Yokota, Yukiko Kaneko, Akihiro Watanabe, Takashi Maeshima, Akiko Miyagi Matsuno, Yoshihiro Harada, Mine Tobinai, Kensei Kobayashi, Yukio BMC Cancer Research Article BACKGROUND: It remains unknown whether primary ocular adnexal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a homogeneous entity, as there are few reports of the results of cytogenetic or molecular analyses of these tumors. METHODS: We performed interphase fluorescence in situ hybridization (FISH) analysis to detect translocations and aneuploidy in 34 cases of primary ocular adnexal MALT lymphoma, and reviewed the histopathological findings. Correlations between the results of FISH analysis, the histopathological features and the clinical data were also analyzed. RESULTS: Among the 34 cases, FISH analysis revealed t(14;18)(q32;q21) in one case, trisomy 3 in 21 cases (62%), and trisomy 18 in 16 cases (47%). The cases with trisomy 18 had significantly more prominent lymphoepithelial lesions (LELs) and less nodularity in the tumors. In regard to the clinical correlations, tumors with trisomy 18 were observed predominantly in females and younger patients; also, in the majority of the cases, the tumor was of conjunctival origin. All the cases with recurrence showed trisomy 18 in the tumor. CONCLUSION: Primary ocular adnexal MALT lymphoma is a significantly heterogeneous entity. Cases with trisomy 18 may have unique clinicopathological features. BioMed Central 2006-10-20 /pmc/articles/PMC1630703/ /pubmed/17052360 http://dx.doi.org/10.1186/1471-2407-6-249 Text en Copyright © 2006 Tanimoto et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Tanimoto, Kazuki
Sekiguchi, Naohiro
Yokota, Yukiko
Kaneko, Akihiro
Watanabe, Takashi
Maeshima, Akiko Miyagi
Matsuno, Yoshihiro
Harada, Mine
Tobinai, Kensei
Kobayashi, Yukio
Fluorescence in situ hybridization (FISH) analysis of primary ocular adnexal MALT lymphoma
title Fluorescence in situ hybridization (FISH) analysis of primary ocular adnexal MALT lymphoma
title_full Fluorescence in situ hybridization (FISH) analysis of primary ocular adnexal MALT lymphoma
title_fullStr Fluorescence in situ hybridization (FISH) analysis of primary ocular adnexal MALT lymphoma
title_full_unstemmed Fluorescence in situ hybridization (FISH) analysis of primary ocular adnexal MALT lymphoma
title_short Fluorescence in situ hybridization (FISH) analysis of primary ocular adnexal MALT lymphoma
title_sort fluorescence in situ hybridization (fish) analysis of primary ocular adnexal malt lymphoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1630703/
https://www.ncbi.nlm.nih.gov/pubmed/17052360
http://dx.doi.org/10.1186/1471-2407-6-249
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