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Patterns of antimicrobial resistance in a surgical intensive care unit of a university hospital in Turkey

BACKGROUND: Several studies have reported higher rates of antimicrobial resistance among isolates from intensive care units than among isolates from general patient-care areas. The aims of this study were to review the pathogens associated with nosocomial infections in a surgical intensive care unit...

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Autores principales: Bayram, Aysen, Balci, Iclal
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1633736/
https://www.ncbi.nlm.nih.gov/pubmed/17064415
http://dx.doi.org/10.1186/1471-2334-6-155
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author Bayram, Aysen
Balci, Iclal
author_facet Bayram, Aysen
Balci, Iclal
author_sort Bayram, Aysen
collection PubMed
description BACKGROUND: Several studies have reported higher rates of antimicrobial resistance among isolates from intensive care units than among isolates from general patient-care areas. The aims of this study were to review the pathogens associated with nosocomial infections in a surgical intensive care unit of a university hospital in Turkey and to summarize rates of antimicrobial resistance in the most common pathogens. The survey was conducted over a period of twelve months in a tertiary-care teaching hospital located in the south-eastern part of Turkey, Gaziantep. A total of 871 clinical specimens from 615 adult patients were collected. From 871 clinical specimens 771 bacterial and fungal isolates were identified. RESULTS: Most commonly isolated microorganisms were: Pseudomonas aeruginosa (20.3%), Candida species (15%) and Staphylococcus aureus (12.9%). Among the Gram-negative microorganisms P. aeruginosa were mostly resistant to third-generation cephalosporins (71.3–98.1%), while Acinetobacter baumannii were resistant in all cases to piperacillin, ceftazidime and ceftriaxone. Isolates of S. aureus were mostly resistant to penicillin, ampicillin, and methicillin (82–95%), whereas coagulase-negative staphylococci were 98.6% resistant to methicillin and in all cases resistant to ampicillin and tetracycline. CONCLUSION: In order to reduce the emergence and spread of antimicrobial-resistant pathogens in ICUs, monitoring and optimization of antimicrobial use in hospitals are strictly recommended. Therefore local resistance surveillance programs are of most value in developing appropriate therapeutic guidelines for specific infections and patient types.
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spelling pubmed-16337362006-11-03 Patterns of antimicrobial resistance in a surgical intensive care unit of a university hospital in Turkey Bayram, Aysen Balci, Iclal BMC Infect Dis Research Article BACKGROUND: Several studies have reported higher rates of antimicrobial resistance among isolates from intensive care units than among isolates from general patient-care areas. The aims of this study were to review the pathogens associated with nosocomial infections in a surgical intensive care unit of a university hospital in Turkey and to summarize rates of antimicrobial resistance in the most common pathogens. The survey was conducted over a period of twelve months in a tertiary-care teaching hospital located in the south-eastern part of Turkey, Gaziantep. A total of 871 clinical specimens from 615 adult patients were collected. From 871 clinical specimens 771 bacterial and fungal isolates were identified. RESULTS: Most commonly isolated microorganisms were: Pseudomonas aeruginosa (20.3%), Candida species (15%) and Staphylococcus aureus (12.9%). Among the Gram-negative microorganisms P. aeruginosa were mostly resistant to third-generation cephalosporins (71.3–98.1%), while Acinetobacter baumannii were resistant in all cases to piperacillin, ceftazidime and ceftriaxone. Isolates of S. aureus were mostly resistant to penicillin, ampicillin, and methicillin (82–95%), whereas coagulase-negative staphylococci were 98.6% resistant to methicillin and in all cases resistant to ampicillin and tetracycline. CONCLUSION: In order to reduce the emergence and spread of antimicrobial-resistant pathogens in ICUs, monitoring and optimization of antimicrobial use in hospitals are strictly recommended. Therefore local resistance surveillance programs are of most value in developing appropriate therapeutic guidelines for specific infections and patient types. BioMed Central 2006-10-25 /pmc/articles/PMC1633736/ /pubmed/17064415 http://dx.doi.org/10.1186/1471-2334-6-155 Text en Copyright © 2006 Bayram and Balci; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bayram, Aysen
Balci, Iclal
Patterns of antimicrobial resistance in a surgical intensive care unit of a university hospital in Turkey
title Patterns of antimicrobial resistance in a surgical intensive care unit of a university hospital in Turkey
title_full Patterns of antimicrobial resistance in a surgical intensive care unit of a university hospital in Turkey
title_fullStr Patterns of antimicrobial resistance in a surgical intensive care unit of a university hospital in Turkey
title_full_unstemmed Patterns of antimicrobial resistance in a surgical intensive care unit of a university hospital in Turkey
title_short Patterns of antimicrobial resistance in a surgical intensive care unit of a university hospital in Turkey
title_sort patterns of antimicrobial resistance in a surgical intensive care unit of a university hospital in turkey
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1633736/
https://www.ncbi.nlm.nih.gov/pubmed/17064415
http://dx.doi.org/10.1186/1471-2334-6-155
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