Mutation Analysis of hCDC4 in AML Cells Identifies a New Intronic Polymorphism

hCDC4 (FBW7, FBXW7) is a new potential tumor suppressor gene which provides substrate specificity for SCF (Skp–Cullin–F-box) ubiquitin ligases and thereby regulates the degradation of potent oncogenes such as cyclin E, Myc, c-Jun and Notch. Mutations in the hCDC4 gene have been found in several soli...

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Detalles Bibliográficos
Autores principales: Nowak, Daniel, Mossner, Maximilian, Baldus, Claudia D., Hopfer, Olaf, Thiel, Eckhard, Hofmann, Wolf-Karsten
Formato: Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2006
Materias:
Short Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1633823/
https://www.ncbi.nlm.nih.gov/pubmed/17088941

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