Morphologic and immunophenotypic evidence of in-situ Kaposi's sarcoma

BACKGROUND: The spectrum of Kaposi's sarcoma (KS) has been expanded to include pre-KS lesions. CASE PRESENTATION: We report, for the first time, a case providing direct histological evidence of the development of early (in-situ) KS from mediastinal lymphatic vessels in the setting of chronic ly...

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Autores principales: Konstantinopoulos, Panagiotis A, Dezube, Bruce J, Pantanowitz, Liron
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1634748/
https://www.ncbi.nlm.nih.gov/pubmed/17074096
http://dx.doi.org/10.1186/1472-6890-6-7
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author Konstantinopoulos, Panagiotis A
Dezube, Bruce J
Pantanowitz, Liron
author_facet Konstantinopoulos, Panagiotis A
Dezube, Bruce J
Pantanowitz, Liron
author_sort Konstantinopoulos, Panagiotis A
collection PubMed
description BACKGROUND: The spectrum of Kaposi's sarcoma (KS) has been expanded to include pre-KS lesions. CASE PRESENTATION: We report, for the first time, a case providing direct histological evidence of the development of early (in-situ) KS from mediastinal lymphatic vessels in the setting of chronic lymphedema in an HIV-positive patient. Spindle-shaped and endothelial cells in these early KS-appearing lesions were immunoreactive for HHV8, D2-40 and CD34. CONCLUSION: Our findings suggest that HHV8-infected spindle-shaped cells associated with lymphangiogenesis that evolve into KS lesions, acquire from the outset an aberrant mixed vascular and lymphatic endothelial cell phenotype.
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spelling pubmed-16347482006-11-04 Morphologic and immunophenotypic evidence of in-situ Kaposi's sarcoma Konstantinopoulos, Panagiotis A Dezube, Bruce J Pantanowitz, Liron BMC Clin Pathol Case Report BACKGROUND: The spectrum of Kaposi's sarcoma (KS) has been expanded to include pre-KS lesions. CASE PRESENTATION: We report, for the first time, a case providing direct histological evidence of the development of early (in-situ) KS from mediastinal lymphatic vessels in the setting of chronic lymphedema in an HIV-positive patient. Spindle-shaped and endothelial cells in these early KS-appearing lesions were immunoreactive for HHV8, D2-40 and CD34. CONCLUSION: Our findings suggest that HHV8-infected spindle-shaped cells associated with lymphangiogenesis that evolve into KS lesions, acquire from the outset an aberrant mixed vascular and lymphatic endothelial cell phenotype. BioMed Central 2006-10-30 /pmc/articles/PMC1634748/ /pubmed/17074096 http://dx.doi.org/10.1186/1472-6890-6-7 Text en Copyright © 2006 Konstantinopoulos et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Konstantinopoulos, Panagiotis A
Dezube, Bruce J
Pantanowitz, Liron
Morphologic and immunophenotypic evidence of in-situ Kaposi's sarcoma
title Morphologic and immunophenotypic evidence of in-situ Kaposi's sarcoma
title_full Morphologic and immunophenotypic evidence of in-situ Kaposi's sarcoma
title_fullStr Morphologic and immunophenotypic evidence of in-situ Kaposi's sarcoma
title_full_unstemmed Morphologic and immunophenotypic evidence of in-situ Kaposi's sarcoma
title_short Morphologic and immunophenotypic evidence of in-situ Kaposi's sarcoma
title_sort morphologic and immunophenotypic evidence of in-situ kaposi's sarcoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1634748/
https://www.ncbi.nlm.nih.gov/pubmed/17074096
http://dx.doi.org/10.1186/1472-6890-6-7
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AT pantanowitzliron morphologicandimmunophenotypicevidenceofinsitukaposissarcoma

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