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Controlling activation of the RNA-dependent protein kinase by siRNAs using site-specific chemical modification

The RNA-dependent protein kinase (PKR) is activated by binding to double-stranded RNA (dsRNA). Activation of PKR by short-interfering RNAs (siRNAs) and stimulation of the innate immune response has been suggested to explain certain off-target effects in some RNA interference experiments. Here we sho...

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Detalles Bibliográficos
Autores principales:	Puthenveetil, Sujiet, Whitby, Landon, Ren, Jin, Kelnar, Kevin, Krebs, Joseph F., Beal, Peter A.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2006
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635244/ https://www.ncbi.nlm.nih.gov/pubmed/16982647 http://dx.doi.org/10.1093/nar/gkl464

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