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A strand-passage conformation of DNA gyrase is required to allow the bacterial toxin, CcdB, to access its binding site
DNA gyrase is the only topoisomerase able to introduce negative supercoils into DNA. Absent in humans, gyrase is a successful target for antibacterial drugs. However, increasing drug resistance is a serious problem and new agents are urgently needed. The naturally-produced Escherichia coli toxin Ccd...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2006
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635281/ https://www.ncbi.nlm.nih.gov/pubmed/16963775 http://dx.doi.org/10.1093/nar/gkl636 |