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Homing endonuclease I-CreI derivatives with novel DNA target specificities

Homing endonucleases are highly specific enzymes, capable of recognizing and cleaving unique DNA sequences in complex genomes. Since such DNA cleavage events can result in targeted allele-inactivation and/or allele-replacement in vivo, the ability to engineer homing endonucleases matched to specific...

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Detalles Bibliográficos
Autores principales:	Rosen, Laura E., Morrison, Holly A., Masri, Selma, Brown, Michael J., Springstubb, Brendan, Sussman, Django, Stoddard, Barry L., Seligman, Lenny M.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2006
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635285/ https://www.ncbi.nlm.nih.gov/pubmed/16971456 http://dx.doi.org/10.1093/nar/gkl645

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