Amino acid residues critical for RNA-binding in the N-terminal domain of the nucleocapsid protein are essential determinants for the infectivity of coronavirus in cultured cells

The N-terminal domain of the coronavirus nucleocapsid (N) protein adopts a fold resembling a right hand with a flexible, positively charged β-hairpin and a hydrophobic palm. This domain was shown to interact with the genomic RNA for coronavirus infectious bronchitis virus (IBV) and severe acute resp...

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Detalles Bibliográficos
Autores principales: Tan, Yong Wah, Fang, Shouguo, Fan, Hui, Lescar, Julien, Liu, D.X.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635287/
https://www.ncbi.nlm.nih.gov/pubmed/16971454
http://dx.doi.org/10.1093/nar/gkl650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635287/
https://www.ncbi.nlm.nih.gov/pubmed/16971454
http://dx.doi.org/10.1093/nar/gkl650

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