Genomic presence of recombinant porcine endogenous retrovirus in transmitting miniature swine

The replication of porcine endogenous retrovirus (PERV) in human cell lines suggests a potential infectious risk in xenotransplantation. PERV isolated from human cells following cocultivation with porcine peripheral blood mononuclear cells is a recombinant of PERV-A and PERV-C. We describe two diffe...

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Detalles Bibliográficos
Autores principales: Martin, Stanley I, Wilkinson, Robert, Fishman, Jay A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635704/
https://www.ncbi.nlm.nih.gov/pubmed/17081300
http://dx.doi.org/10.1186/1743-422X-3-91
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author Martin, Stanley I
Wilkinson, Robert
Fishman, Jay A
author_facet Martin, Stanley I
Wilkinson, Robert
Fishman, Jay A
author_sort Martin, Stanley I
collection PubMed
description The replication of porcine endogenous retrovirus (PERV) in human cell lines suggests a potential infectious risk in xenotransplantation. PERV isolated from human cells following cocultivation with porcine peripheral blood mononuclear cells is a recombinant of PERV-A and PERV-C. We describe two different recombinant PERV-AC sequences in the cellular DNA of some transmitting miniature swine. This is the first evidence of PERV-AC recombinant virus in porcine genomic DNA that may have resulted from autoinfection following exogenous viral recombination. Infectious risk in xenotransplantation will be defined by the activity of PERV loci in vivo.
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spelling pubmed-16357042006-11-11 Genomic presence of recombinant porcine endogenous retrovirus in transmitting miniature swine Martin, Stanley I Wilkinson, Robert Fishman, Jay A Virol J Short Report The replication of porcine endogenous retrovirus (PERV) in human cell lines suggests a potential infectious risk in xenotransplantation. PERV isolated from human cells following cocultivation with porcine peripheral blood mononuclear cells is a recombinant of PERV-A and PERV-C. We describe two different recombinant PERV-AC sequences in the cellular DNA of some transmitting miniature swine. This is the first evidence of PERV-AC recombinant virus in porcine genomic DNA that may have resulted from autoinfection following exogenous viral recombination. Infectious risk in xenotransplantation will be defined by the activity of PERV loci in vivo. BioMed Central 2006-11-02 /pmc/articles/PMC1635704/ /pubmed/17081300 http://dx.doi.org/10.1186/1743-422X-3-91 Text en Copyright © 2006 Martin et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Martin, Stanley I
Wilkinson, Robert
Fishman, Jay A
Genomic presence of recombinant porcine endogenous retrovirus in transmitting miniature swine
title Genomic presence of recombinant porcine endogenous retrovirus in transmitting miniature swine
title_full Genomic presence of recombinant porcine endogenous retrovirus in transmitting miniature swine
title_fullStr Genomic presence of recombinant porcine endogenous retrovirus in transmitting miniature swine
title_full_unstemmed Genomic presence of recombinant porcine endogenous retrovirus in transmitting miniature swine
title_short Genomic presence of recombinant porcine endogenous retrovirus in transmitting miniature swine
title_sort genomic presence of recombinant porcine endogenous retrovirus in transmitting miniature swine
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635704/
https://www.ncbi.nlm.nih.gov/pubmed/17081300
http://dx.doi.org/10.1186/1743-422X-3-91
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AT wilkinsonrobert genomicpresenceofrecombinantporcineendogenousretrovirusintransmittingminiatureswine
AT fishmanjaya genomicpresenceofrecombinantporcineendogenousretrovirusintransmittingminiatureswine

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