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Endothelin-1 enhances fibrogenic gene expression, but does not promote DNA synthesis or apoptosis in hepatic stellate cells

BACKGROUND: In liver injury, the pool of hepatic stellate cell (HSC) increases and produces extracellular matrix proteins, decreasing during the resolution of fibrosis. The profibrogenic role of endothelin-1 (ET-1) in liver fibrosis remains disputed. We therefore studied the effect of ET-1 on prolif...

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Detalles Bibliográficos
Autores principales:	Koda, Masahiko, Bauer, Michael, Krebs, Anja, Hahn, Eckhart G, Schuppan, Detlef, Murawaki, Yoshikazu
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2006
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635728/ https://www.ncbi.nlm.nih.gov/pubmed/17062135 http://dx.doi.org/10.1186/1476-5926-5-5

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